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Anupam Agarwal, MD

Anupam Agarwal, MD
 
Professor and Director
Department of Medicine
Division of Nephrology
Marie S. Ingalls Endowed Chair in Nephrology Leadership
Executive Vice Dean, UAB School of Medicine
University of Alabama at Birmingham, Birmingham, AL
Staff Physician, Birmingham VA Medical Center
THT 647
Phone: (205) 996-6670
E-mail: agarwal@uab.edu

Dr. Agarwal graduated with honors from Kasturba Medical College in India. He completed his residency at the Postgraduate Institute of Medical Education and Research in India, where he also completed a nephrology fellowship.

Dr. Agarwal was a nephrology fellow at the University of Minnesota Hospital and Clinic in Minneapolis. He then joined the Division of Nephrology, Hypertension, and Transplantation at the University of Florida in Gainesville as an assistant professor and was promoted to tenured associate professor. He was promoted to the rank of Professor at UAB in October 2005 and was named the Thomas E. Andreoli Professor of Nephrology in September 2006. He was appointed Division Director for Nephrology at UAB in January 2008 and Vice Chair for Research for the UAB Department of Medicine in October 2009. He was appointed to the Marie S. Ingalls Endowed Chair in Nephrology Leadership in April 2011 and served as Interim Chairman for the UAB Department of Medicine (August 1, 2011-August 31, 2012). Dr. Agarwal also served as the Interim Senior Vice President and Dean, UAB School of Medicine from Feb 2013-Oct 2013.

Education Training:

  • (1980-1985) MBBS - Kasturba Medical College, Mangalore University, India
  • (1985-1986) Internship - Government Wenlock & Lady Goschen Hospitals, Mangalore, India
  • (1986-1989) Junior Resident, MD, Internal Medicine - Postgraduate Institute of Medical Education & Research, Chandigarh, India
  • (1989-1992) Senior Resident/Fellow, DM, Nephrology - Postgraduate Institute of Medical Education & Research, Chandigarh, India
  • (1992-1995) Fellow in Nephrology - Division of Nephrology, University of Minnesota Hospital & Clinic, Minneapolis, Minnesota
  • (1995-1996) Fellow/Instructor - Division of Nephrology, Hypertension & Transplantation, College of Medicine, University of Florida, Gainesville, Florida

Research Description:

Regulation of heme oxygenase gene expression in kidney and vascular injury

Dr. Agarwal's principal interests in clinical nephrology include acute renal failure, specifically in the intensive care unit setting, toxic nephropathies, fluid and electrolyte disorders, glomerular disorders, progression of renal disease, and diabetic nephropathy. His long term goals are to pursue a career in academic nephrology with the primary focus being on basic research, teaching and patient care. His goal is to apply knowledge gained from bench research to the bedside, enabling research to be a significant contributor to advancement in clinical medicine. Dr. Agarwal’s research efforts include three main areas. (i) His laboratory is studying the molecular regulation of the human heme oxygenase-1 (HO-1) gene in renal injury and in atherosclerosis. Induction of this gene occurs as an adaptive and beneficial response to injury and is protective in several clinically important conditions such as acute renal failure, transplant rejection, angiogenesis and atherosclerosis. Studies are focused on identifying regulatory regions in the human HO-1 gene that mediate induction in response to stimuli such as heme, cytokines, nitric oxide, modified lipids and growth factors (eg. transforming growth factor-beta). The studies involve molecular biology techniques to study DNA-protein interactions using chromatin structure analysis, in vivo footprinting, site-directed mutagenesis and gel shift assays. His laboratory is also studying the molecular and biological effects of nitrated lipids on HO-1 gene expression in endothelial cells and in the vasculature. (ii) The functional significance of HO-1 gene expression is also being evaluated using both in vitro and in vivo systems in transgenic animal models of acute renal injury, transplantation and atherosclerosis. (iii) His laboratory is actively pursuing gene delivery approaches in the kidney and the vasculature in animal models of transplantation using recombinant adeno-associated viral vectors. Alternate serotypes and capsid mutants of adeno-associated viral vectors are being developed to maximize gene transfer to the otherwise resistant vascular compartment in the kidney.

NORC Members Research Spotlight

 

Publications

  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • pre2012
  1. Hull TD, Boddu R, Guo L, Tisher CC, Traylor AM, Patel B, Joseph R, Prabhu SD, Suliman HB, Piantadosi CA, Agarwal A, George JF. Heme oxygenase-1 regulates cardiac mitochondrial quality control. Journal of Clinical Investigation Insight, 2016, In press.
  2. Bolisetty S, Traylor A, Joseph R, Zarjou A, Agarwal A. Proximal tubule targeted heme oxygenase-1 in cisplatin-induced acute kidney injury. American Journal of Physiology, Renal Physiology, 2016, In press.
  3. Rao S, Walters K, Wilson L. Johnson A, Chen B, Bolisetty S, Graves D, Barnes S, Agarwal A, Kabarowski JH. Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging. American Journal of Physiology, Renal Physiology, 2016, In press.
  4. Aggarwal S, Lam A, Bolisetty S, Carlisle MA, Traylor A, Agarwal A, Matalon S. Heme attenuation ameliorates irritant gas inhalation induced acute lung injury. Antioxidants and Redox Signaling, 2016;24:99-112. PMC Journal –In process.
  1. Chinta KC, Saini V, Glasgow JN, Siegal GP, Nhamoyebonde S, Rahman MA, Shen H, Wells RM, Traylor AM, Madansein R, Alexander GR, Antony VB, Deshane J, Agarwal A, Steyn AJC. Heme Oxygenase-1 regulates myeloid cell inflammation and immunopathology in human tuberculosis. Submitted to the PNAS, 2015.
  2. Bolisetty S, Zarjou A, Hull TD, Traylor A, Perianayagam A, Joseph R, Kamal AI, Arosio P, Soares MP, Jeney V, Balla J, George JF, Agarwal A. Macrophage and epithelial cell H-Ferritin expression regulates renal inflammation. Kidney International, 2015; 88:95-108. PMCID: PMC4490000
  3. Boddu R, Hull TD, Bolisetty S, Hu X, Moehle MS, Daher JPL, Kamal AI, George JF, Agarwal A, Curtis LM, West AB. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Human Molecular Genetics, 2015;24:4078-4093. PMCID: PMC4476452
  4. Hoyt K, Warram JM, Wang D, Ratnayaka S, Traylor A, Agarwal A. Molecular ultrasound imaging of tissue inflammation using an animal model of acute kidney injury. Molecular Imaging and Biology. 2015; 17:786-792. PMC Journal – In process.
  5. Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov SB, Carter AB, Rowe SM, Matalon S, Thannickal VJ, Agarwal A, Antony VB. Heme oxygenase-1 mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium treated mice. Am J Physiol Lung Cell Mol Physiol. 2015;309:L280-L292. PMCID: PMC4525122.
  6. Li FJ, Duggal RN, Oliva OM, Karki S, Surolia R, Wang Z, Watson RD, Thannickal VJ, Powell M, Watts S, Kulkarni T, Batra H, Bolisetty S, Agarwal A, Antony VB. Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial injury across species. PloS One. 2015;10:e0122275. PMCID: PMC4383564
  7. Surolia R, Karki S, Wang Z, Batra H, Li FJ, Kulkarni T, Thannickal VJ, Steyn AJC, Agarwal A, Antony V. Heme oxygenase-1 determines responses to non-tuberculous mycobacterial infections in aging. Submitted to Am J Physiol Lung Cell Mol Physiol. 2015.
  8. Hull TD, Kamal AI, Boddu R, Bolisetty S, Guo L, Tisher CC, Rangarajan S, Chen B, Curtis LM, George JF, Agarwal A. Heme oxygenase-1 regulates myeloid cell trafficking in acute kidney injury. J Am Soc Nephrol, 2015;26:2139-2151. PMCID: PMC4552119. Accompanying editorial by Kinsey G. Myeloid cell HO-ming in AKI. JASN, 2015.
  1. Khan S, Guo L, Cimbaluk DJ, Elshabrawy H, Faridi MH, Jolly M, George JF, Agarwal A. Gupta V. A small molecule β2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy. Frontiers in Medicine, 2014; 1:45. PMCID: PMC4291902.
  2. Batra K, Czifra A, Kun C, Pall A, Kulcsar J, Paragh G, Lorincz I, Padra TJ, Agarwal A, Zarjou A, Balla J, Szabo Z. Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis. Clinical Experimental Nephrology 2014; 18:952-959. PMC Journal – In process.
  3. Hovater MB, Ying WZ, Agarwal A, Sanders PW. Nitric oxide and carbon monoxide antagonize TGF-b through ligand-independent internalization of TbR1/ALK5. Am J Physiol Renal Physiol. 2014; 307:F727-F735. PMCID: PMC4166728
  4. Hull TD, Agarwal A. Bilirubin: a potential biomarker and therapeutic target for diabetic nephropathy. Diabetes 2014;63:2613-2616. PMCID: PMC4113062
  1. Zolak J, Jagirdar R, Surolia R, Oliva O. Karki S, Hock T, Guroji P, Ding Q, Liu RM, Bolisetty S, Agarwal A, Thannickal V, Antony V. Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury. American Journal of Pathology. 2013; 182:1239-1247. PMCID: PMC3620419.
  2. Czifra A, Pall A, Kulcsar J, Barta K, Kertesz A, Paragh G, Lorincz I, Jenei Z, Agarwal A, Zarjou A, Balla J, Szabo Z. Hemodialysis and hemodiafiltration differentially modulate left ventricular diastolic function. BMC Nephrology, 2013; 14: 76. PMCID: PMC3636119.
  3. Bolisetty S, Traylor AM, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar VM, Agarwal A. Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells. Am J Physiol Renal Physiol. 2013; 305:F255-F264. PMCID: PMC3742869.
  4. Hull TD, Bolisetty S, Dealmeida AC, Litovsky SH, Prabhu SD, Agarwal A, George JF. Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase. Lab Invest. 2013; 93:868-879. PMCID: PMC3729748.
  5. Zarjou A, Bolisetty S, Joseph R, Traylor A, Apostolov EO, Arosio P, Balla J, Verlander J, Darshan D, Kuhn LC, Agarwal A. Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury. Journal of Clinical Investigation, 2013; 123;4423-4434. PMCID: PMC3784534.
  1. Kim J, Zarjou A, Traylor AM, Hull TD, Jaimes EA, George JF, Mikhail FM, Agarwal A. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney International. 2012;82:278-91. PMCID: PMC3396739. Accompanying commentary by Salom MG and Bonacasa B. Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation. Kidney International, 2012:82:253-255.
  2. Kelpke SS, Chen B, Bradley K, Teng X, Chumley P, Moore B, head H, Viera L. Thompson JA, Crossman DK, Bray MS, Eckhoff DE, Agarwal A, Patel RP. Sodium nitrite therapy protects against brain death induced kidney injury and improves post-transplantation outcomes. Kidney International. 2012;82;304-313. PMCID: PMC3412933
  3. Zarjou A, Guo L, Sanders PW, Mannon RB, Agarwal A, George JF. A reproducible mouse model of chronic allograft nephropathy with vasculopathy. Kidney International 2012;82:1231-1235. PMCID: PMC3495090, Featured on Cover of Kidney International, December 1, 2012 issue.
  4. 111.
  5. Regev D, Surolia R, Karki S, Zolak J, Montes-Worboys A, Oliva O, Guroji P, Saini V, Steyn AJC, Agarwal A, Antony VB. Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Laboratory Investigation, 2012;92:1541-1552. PMCID: PMC4017357
  6. Schoeb TR, Jarmi T, Hicks JM, Henke S, Zarjou A, Hitoshi S, Kramer P, Novak J, Agarwal A, Bullard DC. Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice. Arthritis and Rheumatism. 2012;64:4114-4124. PMCID: PMC3510336
  7. Zarjou A, Agarwal A. Superoxide in AVF dysfunction: New target for intervention. American Journal of Physiology: Renal Physiology. 2012;303:F1599-F1600. PMCID: PMC3532471
  8. Guo L, Agarwal A, George JF. Orthotopic aortic transplantation in mice for the study of vascular disease. Journal of Visualized Experiments. 2012. 69; e4338.

1986

  1. Agarwal A. Plasma membrane. Science Reporter 1986 (March);132.

1987

  1. Agarwal A, Kochhar R, Nepalia S, Wig JD, Mehta SK. Cholecystectomy and carcinoma colon. Journal of the Associations of Physicians of India 1987;35:799-800.

1988

  1. Kumar A, Agarwal A. Diabetes mellitus and nail growth. Bulletin of the Voluntary Health Services 1988;28:20-24.

1990

  1. Agarwal A, Sakhuja V, Chugh KS. Fluconazole – induced thrombocytopenia. Annals of Internal Medicine 1990;113:899.

1991

  1. Agarwal A, Anand IS, Sakhuja V, Chugh KS. Effect of dialysis and renal transplantation on autonomic dysfunction in chronic renal failure. Kidney International 1991; 40:489-495.
  2. Acharya DU, Chandrashekhar Y, Agarwal A, Anand IS. Lack of pain during myocardial infarction in diabetics – Is autonomic dysfunction responsible? American Journal of Cardiology 1991; 68:793-796.
  3. Agarwal A, Gupta A, Sakhuja V, Talwar P, Joshi K, Chugh KS. Retinitis following disseminated cryptococcosis in a renal allograft recipient – Efficacy of oral fluconazole. Acta Ophthalmologica 1991;69:402-405.

1992

  1. Agarwal A, Sakhuja V, Malik N, Joshi K, Chugh KS. The diagnostic value of CT scan in acute renal cortical necrosis. Renal Failure 1992; 14: 193-196.
  2. Sandhu JS, Agarwal A, Gupta K, Sakhuja V, Chugh KS. Acute renal failure in severe hypothermia. Renal Failure 1992; 14: 591-594.
  3. Agarwal A, Jha V, Das T, Sakhuja V, Chugh KS. Efficacy of oral fluconazole in 22itrolinolei neoformans infection. Journal of the Association of Physicians of India 1992; 40: 267-268.

1993

  1. Chugh KS, Sakhuja V, Agarwal A, Jha V, Joshi KJ, Dutta BN, Gupta A, Gupta KL. Hereditary nephritis (Alport’s syndrome): Clinical profile and inheritance in 28 Indian kindreds. Nephrology Dialysis and Transplantation 1993; 8:690-695.
  2. Gupta A, Agarwal A, Bansal RK, Agarwal A, Chugh KS. Ischemic central retinal vein occlusion in the young. Eye 1993; 7:138-142.
  3. Agarwal A, Baliga KV, Chandrashekhar YC, Anand IS, Sakhuja V, Chugh KS. Mechanisms of orthostatic hypotension in progressive autonomic failure. Journal of the Association of Physicians of India 1993;41:531-532.

1995

  1. Agarwal A, Balla J, Alam J, Croatt AJ, Nath KA. Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat. Kidney International 1995;48:1298-1307.
  2. 15.
  3. Agarwal A, Mauer SM, Matas A, Nath KA. Recurrent Hemolytic Uremic Syndrome in an adult renal allograft recipient: Current Concepts and Management. Journal of the American Society of Nephrology 1995;6:1160-1169.

1996

  1. Agarwal A, Balla J, Balla G, Croatt AJ, Vercellotti GM, Nath KA. Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL. American Journal of Physiology (Renal, Fluid and Electrolyte 40): 1996;271:F814-F823.
  2. Agarwal A, Kim Y, Matas AJ, Alam J, Nath KA. Gas-generating systems in acute renal allograft rejection in the rat: Co-induction of heme oxygenase and nitric oxide synthase. Transplantation 1996;61:93-98.

1997

  1. Silkensen J, Agarwal A, Nath KA, Rosenberg ME. Temporal induction of clusterin in cisplatin nephrotoxicity. Journal of the American Society of Nephrology 1997;8:302-305.
  2. Castillo D, Agarwal A, Jaimes E, Raij L. Glomerular and vascular tissues do not down-regulate nitric oxide synthesis during protracted endotoxemia. Kidney International 1997;52:460-467.

1998

  1. Agarwal A, Shiraishi F, Visner GA, Nick HS. Linoleyl hydroperoxide transcriptionally upregulates heme oxygenase-1 gene expression in human renal epithelial and aortic endothelial cells. Journal of the American Society of Nephrology 1998;9:1990-1997

1999

  1. Agarwal A and Wingo CS. Treating severe hypokalemia. New England Journal of Medicine 1999;340:154-155 (letter).
  2. Fogg S, Agarwal A, Nick HS, Visner GA. Iron regulates hyperoxia-dependent human heme oxygenase-1 gene expression in pulmonary endothelial cells. American Journal of Respiratory Cell and Molecular Biology 1999;20:797-804.

2000

  1. Shiraishi F, Curtis LM, Truong L, Poss K, Visner GA, Madsen KM, Nick HS, Agarwal A. Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. American Journal of Physiology (Renal). 2000;278:F726-F736.
  2. Hill-Kapturczak N, Truong L, Thamilselvan V, Visner GA, Nick HS, Agarwal A. Smad 7-dependent regulation of heme oxygenase-1 gene expression by transforming growth factor-β in human renal epithelial cells. Journal of Biological Chemistry 2000;275:40904-40909.

2001

  1. Flotte T, Agarwal A, S Song, J Wang, K Chesnut, C Wasserfall, M Kapturczak, T Ellis, H Nick, & M Atkinson. Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes 2001;50:515-520.
  2. Shiraishi F, Visner GA, Nick HS, Agarwal A. Geneticin induces heme oxygenase-1 expression. Implication in transfection studies. Analytical Biochemistry 2001;289:303-305.
  3. Davis CD, Nick HS, Agarwal A. Manganese superoxide dismutase attenuates cisplatin-induced renal injury: Importance of superoxide. Journal of the American Society of Nephrology 2001;12:2683-2690.
  4. Hill-Kapturczak N, Feiyan L, Thamilselvan V, Nick HS, Agarwal A. Mechanism of heme oxygenase-1 gene expression by curcumin in human proximal tubule cells. American Journal of Physiology (Renal) 2001;281:F851-F859.

2002

  1. Chang Se-Ho, Barbosa-Tessmann I, Chen C, Kilberg MS, Agarwal A. Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response. Journal of Biological Chemistry 2002;277:1933-1940.
  2. Kapturczak M, Zolotukhin S, Cross J, Inverardi L, Damaris R, Pileggi A, Byrne B, Ricordi C, Flotte TR, Nick HS, Atkinson M, Agarwal A. Transduction of human and murine pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Molecular Therapy 2002;5:154-160.
  3. Fritz JJ, Lewin A, Hauswirth W, Agarwal A, Grant M, Shaw L. Development of hammerhead ribozyme to modulate endogenous gene expression for functional studies. Methods 2002;28:276-285.

2003

  1. Visner GA, Lu F, Zhou H, Liu J, Kazemfar K, Agarwal A. Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: Implications in the antiproliferative response to rapamycin. Circulation 2003;107:911-916.
  2. Chen S*, Agarwal A*, Glushakova OY, Jorgensen MS, Salgar SK, Amy Poirier, Terence R. Flotte, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology 2003;14:947-958. *Co-first authors. (Figure selected for Cover and accompanying Editorial in same issue)
  3. Chang Se-Ho, Garcia J, Melendez JA, Kilberg MS, Agarwal A. Heme oxygenase-1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron transport chain. Biochemical Journal. 2003;371:877-885.
  4. Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Flotte TR, Ellis TM, Ricordi C, Inverardi L, and Atkinson MA. Adeno-associated virus mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes 2003;52:708-716.
  5. Loiler SA, Conlon TJ, Song S, Warrington KH, Agarwal A, Kapturczak M, Li C, Ricordi C, Atkinson M, Muzyczka N, Flotte TR. Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver. Gene Therapy 2003;10:1551-1558.
  6. Agarwal A, Segal MS. Intimal exuberance: Veins in jeopardy. American Journal of Pathology 2003;162:1759-1761.
  7. Visner GA, Lu F, Zhou H, Lathem C, Agarwal A, Zander DS. Graft protective effects of heme oxygenase-1 in mouse tracheal transplant-related obliterative bronchiolitis. Transplantation 2003;76:650-656.
  8. Hill-Kapturczak N, Sikorski E, Voakes C, Garcia J, Nick HS, Agarwal A. An internal enhancer regulates heme and cadmium-mediated induction of human heme oxygenase-1. American Journal of Physiology (Renal) 2003;285:F515-523.
  9. Hill-Kapturczak N, Voakes C, Garcia J, Visner GA, Nick HS, Agarwal A. A cis-acting region regulates oxidized lipid-mediated induction of the human heme oxygenase-1 gene in endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 2003;23:1416-1412.

2004

  1. Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Immunity to adeno-associated virus serotype 2 delivered transgenes by genetic predisposition to autoimmunity. Gene Therapy 2004;11: 233-240.
  2. Zhou X, Yang G, Davis CA, Doi SQ, Hirszel P, Wingo CS, Agarwal A. Hydrogen peroxide mediates FK506-induced cytotoxicity in renal cells. Kidney International 2004;65:139-147.
  3. Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human MnSOD: Evolutionary conservation of product inhibition. Journal of Biological Chemistry 2004;279:12769-12776.
  4. Chen S, Segal MS, Agarwal A. “Lumen digestion” technique for isolation of aortic endothelial cells from heme oxygenase-1 knockout mice. Biotechniques 2004;37:84-89. 45. Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis TM, Atkinson MA, Agarwal A. Heme oxygenase-1 modulates early inflammatory responses: Evidence from the heme oxygenase-1 deficient mouse. American Journal of Pathology 2004;165:1045-1053.
  5. Hock TD, Nick HS, Agarwal A. Upstream stimulatory factors, USF1 and USF2 bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription. Biochemical Journal 2004;383:209-218.

2005

  1. Cisowski J, Loboda A, Józkowicz A, Chen S, Agarwal A, Dulak J. Role of heme oxygenase-1 in hydrogen peroxide-induced VEGF synthesis: effect of HO-1 knockout. Biochemical Biophysical Research Communications 2005;326:670-676.
  2. Adin CA, Croker BP, Agarwal A. Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated perfused rat kidney. American Journal of Physiology, Renal Physiology 2005;288:F778-F784.
  3. Chen S, Kapturczak MH, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy 2005;16:235-247.
  4. Agarwal A. Measuring Δψm in isolated tubules. Editorial Focus. American Journal of Physiology, Renal Physiology 2005;288:F1090-F1091.
  5. Liby K, Hock TD, Yore MM, Suh N, Place AE, Risingsong R, Williams C, Honda T, Honda Y, Gribble GW, Gadisetti VRC, Hill-Kapturczak N, Agarwal A, Sporn MB. The synthetic triterpenoids, CDDO and CDDO-Imidazolide, are potent inducers of heme oxygenase-1 and the Nrf2/ARE signaling. Cancer Research 2005;65:4789-4798.
  6. Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Hauswirth WW, Madsen KM, Croker BP, Berns, KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin-10 attenuates neointimal proliferation and inflammation in aortic allografts via a heme oxygenase dependent pathway. Proceedings of The National Academy of Sciences, USA 2005;102:7251-7256.
  7. Zhou X, Ferraris JD, Cai Q, Agarwal A, and Burg MB. Increased reactive oxygen species contribute to tonicity-dependent activation of the osmoregulatory transcription factor, TonEBP. American Journal of Physiology, Renal Physiology 2005;289:F377-F385.
  8. Tang Yaoliang, Tang Yi, Zhang CY, Agarwal A, Kasahara H, Qian K, Shen L. Phillips MI. A hypoxia-inducible vigilant vector system for activating therapeutic genes in ischemia. Gene Therapy 2005;12:1163-1170.
  9. Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ. Interleukin-10 suppresses chemokines, inflammation and fibrosis in a model of chronic renal disease. Journal of the American Society of Nephrology 2005;16:3651-3660.
  10. Mark A, Hock T, Kapturczak MH, Agarwal A, Hill-Kapturczak N. Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-β in human renal tubular epithelial cells. Cellular and Molecular Biology 2005;51:357-362.
  11. Wilson KHS, McIndoe RA, Eckenrode S, Morel L, Agarwal A, Croker BP, She JX. Alterations of renal phenotype and gene expression profiles due to protein overload in NOD-related mouse strains. BMC Nephrology 2005;6:17.

2006

  1. Ujhelyi L, Balla G, Jeney V, Varga Z, Nagy W, Vercellotti GM, Agarwal A, Eaton JW, Balla J. Hemodialysis reduces inhibitory effect of plasma ultrafiltrate on LDL oxidation and subsequent endothelial reactions. Kidney International 2006;69:144-151.
  2. Zhou H, Liu H, Porvasnik S, Cheng Y, Terada N, Agarwal A, Visner GA. Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension. Laboratory Investigation 2006;86:62-71.
  3. Basireddy M, Isbell ST, Teng X, Patel RP, Agarwal A. Nitrite does not provide protection in ischemia-reperfusion injury of the rat kidney. American Journal of Physiology, Renal Physiology 2006;290:F779-86.
  4. Kelley EE, Hock T, Khoo NKH, Richardson GR, Johnson KK, Powell PC, Giles GI, Agarwal A, Lancaster JR, Tarpey MM. Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells. Free Radical Biology and Medicine 2006;40:952-959.
  5. Hill-Kapturczak N, Agarwal A. Carbon monoxide: From silent killer to potential remedy. Editorial Focus. American Journal of Physiology, Renal Physiology 2006;290:F787-788.
  6. Wright MM, Schopfer FJ, Baker PRS, Vidyasagar V, Powell P, Chumley P, Iles KE, Freeman BA Agarwal A. Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase-1 expression. Proceedings of the National Academy of Sciences, USA, 2006;103:4299-4304.
  7. Chen S, Wasserfall C, Kapturczak MH, Atkinson MA, Agarwal A. Freeze-thaw increases adeno-associated virus transduction of cells. American Journal of Physiology, Cell Physiology, 2006;291:C386-C392.
  8. Ujhelyi L, Balla G, Jeney V, Varga Z, Nagy W, Vercellotti GM, Agarwal A, Eaton JW, Balla J. Response to p-Cresol for better or worse: But what are we measuring? Kidney Int 2006;70:232-233.
  9. Basireddy M, Lindsay JT, Agarwal A, Balkovetz DF. Epithelial cell polarity and hypoxia influence heme oxygenase-1 expression by heme in renal epithelial cells. American Journal of Physiology, Renal Physiology, 2006; 291:F790-F795.
  10. Sikorski EM, Uo T, Morrison RS, Agarwal A. Pescadillo interacts with the cadmium response element of the human heme oxygenase-1 promoter in renal epithelial cells. Journal of Biological Chemistry, 2006;281:24423-24430.
  11. Cui T, Schopfer FJ, Zhang J, Chen K, Ichikawa T, Baker PRS, Batthyany C, Chacko BK, Feng X, Patel RP, Agarwal A, Freeman BA, Chen YE. Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. Journal of Biological Chemistry, 2006;281:35686-98.
  12. Keum YS, Yu S, Chang PPJ, Yuan X, Kim JH, Xu C, Han J, Agarwal A, Kong T AN. Mechanism of action of sulforaphane: Inhibition of p38 MAPK isoforms contributing to the induction of antioxidant response element (ARE)-mediated heme oxygenase-1 in human hepatoma HepG2 cells. Cancer Res 2006;66: 8804-8813.

2007

  1. Koya S, Crenshaw D, Agarwal A. Rhabdomyolysis and acute renal failure following fire ant bites. Journal of General Internal Medicine, 2007;22:145-147.
  2. Kirby K, Baylis C, Agarwal A, Croker B, Archer L, Adin C. Intravenous bilirubin provides incomplete protection against renal ischemia-reperfusion injury in vivo. American Journal of Physiology, Renal Physiology, 2007;292: F888-F894.
  3. Hock TD, Liby K, Wright MM, McConnel S, Schorpp-Kistner M, Ryan TM, Agarwal A. JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. Journal of Biological Chemistry, 2007;282:6875-6886.
  4. Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S. Adeno-Associated virus mediated interleukin-10 gene delivery prolongs allograft survival in a rat kidney transplant model. American Journal of Transplantation, 2007;7:1112-1120.
  5. Deshane J, Chen S, Chen B, Callabero S, Grochot-Przeczek A, Was H, Li Calzi S, Radoslaw L, Hock TD, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant M, Agarwal A. Stromal cell-derived factor-1 promotes angiogenesis via a heme oxygenase-1 dependent mechanism. Journal of Experimental Medicine, 2007;204:605-618.
  6. Marsh SA, Powell PC, Agarwal A, Dell’Italia LJ, Chatham JC. Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: the role of hydronephrosis. American Journal of Physiology: Heart, Circulatory Physiology, 2007;293:H292-H298.
  7. Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein M, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih D, Agarwal A, Lusis AJ, Araujo JA. Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circulation Research, 2007;100:1703-11.
  8. Bolisetty S, Agarwal A. Subclinical kidney injury incites endotoxin hyperresponsiveness. Editorial Focus. American Journal of Physiology: Renal Physiology, 2007;293:F41-F42.
  9. Roberts J, Chen Bo, Curtis LM, Agarwal A, Sanders PW, Zinn KR. Detection of early changes in renal function using Tc-99m-Mag3 imaging in a murine model of ischemia-reperfusion injury. American Journal of Physiology, Renal Physiology. 2007;293: F1408-F1412.
  10. Curtis LM, Agarwal A. HOpe for Contrast-induced Acute Kidney Injury. Editorial Commentary, Kidney International, 2007;72:907-9.

2008

  1. Dulak J, Deshane J, Jozkowicz A, Agarwal A. Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis. Circulation 2008;117:231-241.
  2. Kumar A, Deshane J, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A and Steyn AJC. Heme oxygenase-1 derived carbon monoxide induces the mycobacterium tuberculosis dormancy regulon. Journal of Biological Chemistry, 2008;283:18032-18039. PMCID: PMC2440631
  3. Kie JH, Kapturczak MH, Traylor A, Agarwal A, Hill-Kapturczak N. Heme oxygenase-1 deficiency exacerbates epithelial-mesenchymal transition and renal fibrosis. Journal of the American Society of Nephrology, 2008;19:1681-1691. PMCID: PMC2518436
  4. George JF, Braun A, Brusko TM, Joseph R, Bolisetty S, Wasserfall CW, Atkinson MA, Agarwal A, Kapturczak MH. Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen presenting cells. American Journal of Pathology, 2008;173:154-160. PMCID: PMC2438293
  5. Curtis LM, Chen S, Chen B, Agarwal A, Klug CA, Sanders PW. Contribution of intra-renal cells to cellular repair after acute kidney injury: Subcapsular implantation technique. Am J Physiol Renal Physiol 2008;295:F310-4. PMCID: PMC2494519
  6. Calzi SL, Purich DL, Chang KH, Afzal A, Busik JV, Agarwal A, Segal MS, Grant MB. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator–stimulated phosphoprotein (VASP) phosphorylation: Evidence for blunted responsiveness in diabetes. Diabetes, 2008;57:2488-2494. PMCID: PMC2518501

2009

  1. Mu W, Long DA, Ouyang X, Agarwal A, Cruz PE, Roncal CA, Nakagawa T, Yu X, Hauswirth WW, Johnson RJ. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol. 2009;296(1):F145-52. PMCID: PMC2636910
  2. Bolisetty S, Agarwal A. Neutrophils and acute kidney injury: Not neutral any more. Editorial commentary, Kidney International, 2009;75:674-676.
  3. Zarjou A, Jeney V, Arosio P, Poli M, Antal-Szalmas P, Agarwal A, Balla G, Balla J. Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells. Journal of the American Society of Nephrology, 2009;20:1254-1263. PMCID: PMC2689905
  4. Ricart KC, Bolisetty S, Johnson MS, Perez J, Agarwal A, Murphy MP, Landar A. The permissive role of mitochondria in the induction of haem oxygenase-1 in endothelial cells. Biochemical Journal, 2009; 419:427-436. NIHMSID #104816
  5. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: 30itrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radical Biology and Medicine, 2009;46:866-875.
  6. Chen B, Guo L, Fan C, Bolisetty S, Joseph R, Wright MM, Agarwal A, George J. Carbon monoxide rescues heme oxygenase-1 deficient mice from arterial thrombosis in allogenic aortic transplantation. American Journal of Pathology, 2009,175: 422-429. PMCID: PMC2708827
  7. Okusa MD, Chertow GM, Portilla D; Acute Kidney Injury Advisory Group of the American Society of Nephrology. The nexus of acute kidney injury, chronic kidney disease, and World Kidney Day 2009. Clin J Am Soc Nephrol. 2009;4:520-522. PMC In process.
  8. Wright, MM, Kim J, Hock TD, Leitinger N, Freeman BA, Agarwal A. Human haem oxygenase-1 induction by nitro-linoleic acid is mediated by cyclic AMP, AP-1, and E-box response element interactions. Biochemical Journal, 2009;422:353-361. PMCID: PMC2881470
  9. Cole MP, Rudolph TK, Khoo NKH, Motanya UN, Golin-Bisello F, Wertz JW, Schopfer FJ, Rudolph V, Woodcock SR, Bolisetty S, Ali MS, Zhang J, Chen YE, Agarwal A, Freeman BA, Bauer PM. Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury. Circulation Research, 2009;105:965-972. PMCID: PMC2784279

2010

  1. Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, Kalyanaraman B, Landar A, Darley-Usmar V. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signaling mechanisms. Biochemical Journal 2010:426:31-41. PMCID: PMC3079364.
  2. George JF, Agarwal A. Hydrogen: another gas with therapeutic potential. Kidney International 2010;77:85-87. Editorial commentary.
  3. Dong JP, Agarwal A, George JF. Heme oxygenase-1 Expression in murine dendritic cell subpopulations: Effect on CD8+ dendritic cell differentiation in vivo, American Journal of Pathology, 2010;176:2831-2839. PMCID: PMC2877844
  4. Deshane, J*, Kim J*, Bolisetty S, Hock TD, Hill-Kapturczak N, Agarwal A. Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells. Journal of Biological Chemistry, 2010;285:16476-1686. * co-first authors. PMCID: PMC2878004
  5. Bolisetty S, Traylor AM, Kim J, Joseph R, Ricart K, Landar A, Agarwal A. Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury. Journal of the American Society of Nephrology, 2010;21:1702-1712. PMCID: PMC3013546. Accompanying editorial commentary by Kapitsinou PP and Haase VH. HO-1 in control of a self-eating kidney. J Am Soc Nephrol 2010;21:1600-1602.
  6. Chacko BK, Reily C, Srivastava A, Johnson MS, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar V. Prevention of diabetic nephropathy in the Ins2+/-Akita J mice by the mitochondria-targeted therapy Mito-Q. Biochemical Journal, 2010, 432:9-19. PMCID: PMC2973231.

2011

  1. Zarjou A, Agarwal A. ATP as a death factor: Purinergic signaling in renal epithelial-fibroblast crosstalk. Editorial Focus. American Journal of Physiology: Renal Physiology, 2011, 300:F60-1.
  2. Zarjou A, Kim J, Traylor AM, Sanders PW, Balla J, Agarwal A, Curtis LM. Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. American Journal of Physiology: Renal Physiology, 2011, 300:F254-62. PMCID: PMC3023217.
  3. Bolisetty S, Agarwal A. Urine albumin as a biomarker in acute kidney injury. Editorial Focus. American Journal of Physiology: Renal Physiology, 2011, 300:F626-F627.
  4. Wu QQ, Wang Y. Senitko M, Meyer C, Wigley CW. Ferguson DA, Grossman E, Chen J, Zhou ZJ, Hartono J, Winterberg P. Chen B, Agarwal A, Lu CY. Bardoxolone Methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes – Nrf2, PPARγ, and HO-1. American Journal of Physiology: Renal Physiology, 2011,300:F1180-92. PMCID: PMC3094059.
  5. Lu A, Miao M, Schoeb, TR, Agarwal A, Murphy-Ullrich JE. Blockade of TSP1-dependent TGF-β activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy. American Journal of Pathology, 2011,178:2573-2586. PMCID: PMC3124297.
  6. Zavaczki E, Jeney V, Agarwal A, Zarjou A, Oros M, Katko M, Varga Z, Balla G, Balla J. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells. Kidney Int. 2011;80:731-9. PMCID: PMC3257044
  7. Zarjou A, Yang S, Abraham E, Agarwal A, Liu G. Identification of a microRNA signature in renal fibrosis: Role of miR21. American Journal of Physiology: Renal Physiology. 2011;301:F793-801. PMCID: PMC3191802