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Fred (Ted) Edmond Bertrand III, PhD

Fred (Ted) Edmond Bertrand III, PhD
 
Associate Professor
Department of Clinical and Diagnostic Sciences
Adjunct Associate Professor, Department of Nutrition Sciences
1720 2nd Ave South
SHPB 473
The University of Alabama at Birmingham
Birmingham, AL 35294-1212
Phone: 205-934-1374 (office, SHPB 473)
205-934-0343 (lab, Webb 235)
Email: fbrtrnd@uab.edu
Full CV
Web Site


Education

B.S. (Applied Biology), Georgia Institute of Technology, Atlanta, GA
Ph.D. (Microbiology), The University of Alabama at Birmingham, Birmingham, AL

Biographical Sketch

Dr. Bertrand joined the UAB faculty in 2014 in the Department of Clinical and Diagnostic Sciences, where he provides instruction in the Biomedical Science Program and the Clinical Laboratory Science Program. He also has an adjunct appointment in the Department of Nutrition Sciences, where he studies the role of Notch-1 signaling in regulating nutrient responses of tumor cells in the microenvironment of epithelial and hematopoietic malignacies. He received his Bachelor of Science degree in Applied Biology from The Georgia Institute of Technology (1990), Ph.D. in Microbiology & Immunology from the University of Alabama at Birmingham (1995) and completed postdoctoral training at the University of Toronto (Ontario, Canada) and the University of Minnesota. Dr. Bertrand has mentored graduate and undergraduate students conducting research in cell signaling, cancer biology and B-cell development.

Research Interests

Our recent interests have focused on interactions between Notch-1 signaling and the mTOR and PTEN/PI3K/Akt pathways. Our goal is to understand how Notch-1 signaling may alter nutrient responses in hematopoietic and epithelial malignancies. We have reported that in prostate cancers, Notch-1 signaling is lost in tumor foci, but is retained in surrounding benign tissues. We have also found that enforced expression of Notch-1 in prostate cell lines results in increased expression of PTEN at the level of transcription, mediated by the Notch-activated transcription factor CBF-1 binding to the PTEN promote. In previous projects, we have characterized Notch-expression as a function of B-cell development, and we have investigated the mechanistic basis for loss of stromal cell and cytokine responsiveness in leukemias bearing the MLL/AF4 fusion. We have had a longstanding interest in how B-lymphocytes develop in normal and leukemic states.

Publications

Link to publications on Pubmed