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Ganesh Halade, PhD

Ganesh Halade, PhD Assistant Professor
Department of Medicine
Division of Cardiovascular Disease
The University of Alabama at Birmingham
310A Zeigler Research Building
1720 2nd Avenue South, Birmingham, Alabama 35294-0007
Office: (205) 996-4139
Lab: (205) 996-4140
E-mail: halade@uab.edu
Full CV

 

Biography:

Dr. Halade received training in cardiovascular sciences with major focus on obesity and cardiac remodeling. After gaining PhD in pharmacology, he completed postdoctoral training with Dr. Merry Lindsey at San Antonio Cardiovascular Proteomics Center and Barshop Institute for Longevity Studies in Aging at the University of Texas Health Science Center. Dr. Halade has spent more than 7 years working on obesity and now focusing on the regulation of inflammation and extracellular matrix following myocardial infarction (MI) in the setting of obesity. He is working on fatty acids and their role in post-MI inflammation and extracellular matrix remodeling. In early career of his training, Dr. Halade worked to segregate distinct effect of docosahexaenoic acid and eicosapentaenoic acid in lupus. In May 2013, Dr. Halade joined as an Assistant Professor in the Division of Cardiovascular Disease, Department of Medicine.

Research Interests:

Cardiac Remodeling in the Setting of Obesity following Myocardial Infarction and Resolution of Inflammation

Research description:

My research focuses on translational and cardiovascular research that includes: (1) Applying multidimensional clinically translational approaches to examine the mechanisms whereby the left ventricle responds to injury in the setting of obesity; (2) Dissecting the effects fatty acids and novel fatty acid derivatives on cardiac remodeling and developing strategies to delay, slow, or reverse the progression to heart failure in obesity; and (3) Communicating the results in the form of presentation, report and manuscripts.

Publications
 

  • 2013
  • 2012
  • 2011
  • Pre 2011
  1. Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin Yu-Fang, Manicone AM, Han HC, Lindsey ML. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture following myocardial infarction in mice. Circ Res. 112: 675-688, 2013.
     
  2. de Castro Brás LE, Ramirez TA, DeLeon KY, Chiao YA, Ma Y, Dai Q, Halade GV, Hakala K, Weintraub ST, Lindsey, ML. Texas 3-step decellularization protocol: Looking at the cardiac extracellular matrix. J Proteo Res. 86: 43-52, 2013.
     
  3. Halade GV*, Williams PJ, Veigas, JM, Barnes JL, Fernandes G. Concentrated fish oil (Lovaza®) extends lifespan and attenuates kidney disease in lupus–prone short-lived (NZBXNZW)F1 mice. Exp Bio Med. 238: 610 – 622, 2013.
     
  4. Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV*. Obese and diabetic KKAy mice show increased mortality but reduced ventricular dysfunction following myocardial infarction. Cardiovasc Pathol (in press)
     
  5. Halade GV*, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler J, Lopez EF, Ghasemi O, Jin YF, Lindsey ML. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. Am J Physiol-Heart C (in press)
     
  6. de Castro Brás LE, Cates CA, DeLeon-Pennell KY, Ma Y, Iyer RP, Halade GV, Yabluchanskiy A, Fields GB, Weintraub ST, Lindsey, ML. Citrate Synthase is a Novel In Vivo Matrix Metalloproteinase-9 Substrate that Regulates Mitochondrial Function in the Post-Myocardial Infarction Left Ventricle. (Resubmitted to Antioxid Redox Signal August 2013)
     
  1. Zamilpa R, Ibarra J, de Castro Bras L, Ramirez TA, Nguyen N, Halade GV, Zhang J, Dai Q, Dayah T, Chiao YA, Ahuja SS, D’Armiento, J, Jin YF, Lindsey ML. Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction. J Mol Cell Card. 53: 599–608, 2012.
     
  2. Wang Y, Jin YF, Ma Y, Halade GV, Lindsey ML. Mathematical modeling of macrophage activation in left ventricular remodeling post-myocardial infarction. BMC Genomics. 13(Suppl 6):S21, 2012.
     
  3. Banu J, Varela E, Guerra JM, Halade GV, Williams PJ, Bahadur AN, Hanaoka K, Fernandes G. Dietary coral calcium and zeolite protects bone in a mouse model for postmenopausal bone loss. Nutr Res. 32(12):965-75, 2012.
     
  1. Halade GV, Rahman MM, Williams PJ, Fernandes G. Combination of conjugated linoleic acid and fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice. J. Nutr Biochem. 22(5): 459-69, 2011.
     
  2. Puranik AS, Halade GV, Sandeep Kumar, Mogre R, Apte K, Vaidya A, Patwardha B. Cassia auriculata: aspects of safety pharmacology and drug interaction. Evid Based Complement and Alternat Med. 2011. (in press)
     
  3. Halade GV*, Jamali AK, Williams PJ, Fajardo RJ, Fernandes G. Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Exp Geronto. 46:1: 43-52, 2011. This article was included in the top 25 hottest articles from October-December 2010.
     
  4. Rahman MM, Halade GV, Fernandes G. t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity. J. Cell Physiol. 226(9: 2406-14, 2011.
     
  5. Halade GV*, Williams PJ, Lindsey ML, Fernandes G. Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice. Pharmacol Res. 63: 4: 300-7, 2011.
     
  6. Veigas JM, Williams PJ, Halade GV, Rahman MM, Yoneda T, Fernandes G. Fish oil concentrate delays sensitivity to thermal nociception in mice. Pharmacol Res. 63(5): 377-82, 2011.
     
  1. Juvekar AR and Halade GV. Hypoglycemic activity of Cassia auriculata in neonatal streptozotocin-induced non-insulin dependent diabetes mellitus in rats. J Nat Remed. 6; (1):14-18, 2006.
     
  2. Halade GV*, Juvekar AR. Effect of Spirulina Platensis pretreatment on isoproterenol induced hyperlipidemia in rats. Pharmacologyonline. (2):243-251, 2006.
     
  3. Deshmane DN, Gadgoli C, Halade GV. Anticonvulsant effects of O. majorana L., Pharmacologyonline. (1): 64-78, 2007.
     
  4. Rahman MM, Halade GV, El Jamali A, Fernandes G. Conjugated linoleic acid (CLA) prevents age associated skeletal muscle loss. Biochem Biophys Res Commun. 12; 383 (4): 513-8, 2009.
     
  5. Halade GV, Rahman MM, Fernandes G. Effect of CLA isomers and their mixture on aging C57Bl/6J mice. Euro J Nutr. 48; (7):409-18, 2009.
     
  6. Rahman MM, Halade GV, Bhattacharya A, Fernandes G. The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR- and SIRTI-1 expression on a caloric restricted diet. Oxid Med Cell Longev. 2:5,307-316, 2009.
     
  7. Halade GV, Rahman MM, Fernandes G. Differential effects of CLA isomers in insulin resistant female C57Bl/6J mice. J. Nutr Biochem. 21(4):332-7, 2010. This article was included in the top 25 hottest articles from April-June 2009 selected by sciencedirect.
     
  8. Halade GV, Rahman MM, Williams PJ, Fernandes G. High fat diet-induced animal model of age-associated obesity and osteoporosis. J. Nutr Biochem. 21: (12):1162-9, 2010. This article was included in the top 25 hottest articles from October-December 2010.
     
  9. Halade GV, Rahman MM, Bhattacharya A, Barnes J, Chandrasekar B, Fernandes G. Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice. J Immunol. 184(9): 5280-6, 2010.