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Jeonga Kim, PhD

Jeonga Kim, PhD
 
Assistant Professor
Department of Medicine
Division of Endocrinology and Metabolism
University of Alabama at Birmingham
UAB Comprehensive Diabetes Center
1808 7th Avenue South
BDB 777
Birmingham, Al 35294-0012
Tel: (205) 934-4128
Fax: (205) 975-9372
E-mail: jakim@uab.edu

Career Path – I graduated from Yonsei University, Seoul, Korea with B.S and M.S degrees in Nutrition and Biochemistry, respectively. I have broad training and extensive experience in area spanning regulation of gene transcription, signal transduction, cell biology, metabolic and vascular animal physiology, and translational studies with an eye towards therapeutic discovery for human diseases. While in graduate school at Iowa State University and during post-doctoral training at Penn State University, I focused on elucidating mechanisms for transcriptional activation. of cAMP responsive element binding protein (CREB) to regulate glucose metabolism in the liver. I received the second post-doctoral training with Dr. Michael Quon in the Diabetes Unit, NIH. Here, I developed deep expertise in signal transduction, particularly related to insulin action and endothelial function. I also gained a more thorough understanding of animal and human physiology and pathophsyiology related to diabetes, obesity, and their cardiovascular complications. After post-doctoral training, I obtained an independent position at the University of Missouri, Columbia. While at Missouri, I expanded my research from basic science to animal physiology and translational research. Since 2010, I have been appointed as a tenure-track Assistant Professor at the University of Alabama, Birmingham (UAB).

Research Focus - My research area focuses on understanding the mechanisms of insulin resistance and endothelial dysfunction. This includes identification and characterization of molecules that are responsible for the saturated fatty acid-mediated inflammatory response in the vasculature that contribute to impairment of insulin signaling and cardiometabolic functions. The research project involves molecular, cellular, and pharmacological tools to investigate physiological roles of eNOS/NO in vasodilation and metabolism. Second research project is to understand the role of vascular autophagy in nutrient metabolism. Since autophagy is one of the essential cellular process in normal and stress conditions, uncovering the roles of vascular autophagy in metabolic disorders will provide additional information to elucidate the relationship between vascular function and metabolism. These projects will help better understanding of physiology and pathophysiology of cross-talk between multiple tissues via vascular endothelium. That being said, we are working on developing pharmacological and molecular strategies to improve public health regarding metabolic disorders.

Education:

1985 BS : Food and Nutrition, Yonsei University, Seoul, Korea
1987 MS : Biochemistry, Yonsei University, Seoul, Korea
1997 PhD: Genetics, Iowa State University

Publications

  1. JA Kim, JE Mayfield. Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase. Biochim Biophys Acta (1997) 1354, 55-57.
  2. JA Kim, Z Sha, JE Mayfield.Brucella abortus periplasmic catalase is regulated in response to external H2O2. Infect Immun (2000) 68, 3861-3866
  3. JA Kim, JE Mayfield. Identification of Brucella abortus OxyR and its Role in Control of Catalase Expression. J Bacteriol (2000) 182, 5631-5633
  4. JS Choi, JA Kim, DH Kim, MH Chun, BJ Gwag, SK Yoon and CK Joo: Failure to activate NF-kB promotes apoptosis of retinal ganglion cells following optic nerve transection. Brain Res (2000) 883, 60-68
  5. JA Kim, J Lu, PG Quinn: Distinct CREB domains stimulate different steps in a concerted mechanism of transcription activation. Proc Natl Acad Sci USA (2000) 97, 11292-11296
  6. EA Felinski, JA Kim, J Lu, PG Quinn: Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation. Mol. Cell. Biol. (2001) 21, 1001-1010
  7. JM Lim, JA Kim, JH Lee, and CK Joo: Downregulated expression of integrin alpha6 by transforming growth factor-b1(TGF-b1) on lens epithelial cells in vitro. Biochem Biophys Res Commun (2001) 284, 33-41
  8. SK Park, JA Kim (co-first), Y Seomun, J Choi , DH Kim, IO Han, EH.Lee, JH Lee, WR Wee, and CK Joo: Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun (2001) 284, 966-971
  9. Y Seomun, JA Kim (co-first), EH Lee, and CK Joo: Overexpression of matrix metalloproteinase-2 mediates phenotypic transformation of lens epithelial cells: Biochem J (2001) 15, 41-48
  10. DH Kim, JA Kim, JS Choi, CK Joo: Activation of caspase-3 during degeneration of ONL in rd mouse retina. Ophthalmic Res (2002) 34, 150-157
  11. MJ Lee, SS Cho, HS J, YS Lim, JR You, J Park, H Suh, JA Kim, JS Park, DK Kim: Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by eletroporation. Exp Mol Med (2002) 34, 265-272
  12. MJ Lee, SS Cho, JR You, Y Lee, BD Kang, JS Choi, JW Park, YL Suh, JA Kim, D-K Kim, J-S Park: Intraperitoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model. Gene Ther (2002) 9, 859-866
  13. JS Choi, JA Kim and CK Joo:Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Invest Ophthalmol Vis Sci. (2003) 44, 1747-1752
  14. J Lyu, JA Kim, SK Chung, KS Kim, CK Joo:Alteration of cadherin in dexamethasone-induced cataract organ-cultured rat lens. Invest Ophthalmol Vis Sci. (2003) 44, 2034-2040
  15. HS Jang, HJ Kim, JM Kim, YS Lee, KL Kim, JA Kim, JY Lee, W Suh, JH Choi, ES Jeon, J Byun, DK Kim: A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of naked plasmid DNA to skeletal muscle: Mol Ther. (2004) 9, 464-74
  16. YS Lee, JA Kim, KL Kim, HS Jang, JM Kim, JY Lee, IS Shin, JS Lee, W Suh, JH Choi, ES Jeon, J Byun, DK Kim: Aldosterone upregulates connective tissue growth factor gene expression via p38 MAPK pathway and mineralocorticoid receptor in ventricular myocytes. J Korean Med Sci. (2004) 9, 805-11
  17. YS Lee, J Byun, JA Kim, JS Lee, KL Kim, YL Suh, JM Kim, HS Jang, JY Lee, IS Shin, W Suh, ES Jeon, DK Kim: Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung. Exp Mol Med. (2005) 28, 27-35
  18. JA Kim, DC Yeh, M Ver, Y Li, A Carranza, TP Conrads, TD Veenstra, MA Harrington, MJ Quon: Phosphorylation of Ser24 in the PH domain of IRS-1 by mPLK/IRAK: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. J Biol Chem. (2005) 280, 23173-83
  19. JA Kim, KK Koh, MJ Quon: The union of vascular and metabolic actions of insulin in sickness and in health. Arterioscler Thromb Vasc Biol. (2005) 25, 889-91
  20. KK Koh, MJ Quon, SH Han, WJ Chung, JY Ahn, JA Kim, Y Lee, EK Shin: Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic, hypertensive patients.  Diabetes Care, (2006) 29, 195-201
  21. G Formoso, H Chen, JA Kim, M Montagnani, A Consoli, MJ Quon: DHEA mimics acute actions of insulin to stimulate production of both NO and ET-1 via distinct PI 3-kinase- and MAP-kinase- dependent pathways in vascular endothelium Mol Endocrinol. (2006) 20, 1153-1163
  22. JA Kim, M Montagnani, KK Koh, MJ Quon: Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: molecular and pathophysiological mechanisms Circulation (2006) 113, 1888-904
  23. KK Koh, MJ Quon, SH Han, WJ Chung, JA Kim, EK Shin: Vascular and metabolic effects of candesartan: insights from therapeutic interventions. J. Hypertens Suppl. (2006), 24, S31-8.
  24. MW Greene, MS Ruhoff, RA Roth, JA Kim, MJ Quon, JA Krause: PKC-d mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function. : Biochem Biophys Res Commun (2006) 349, 976-986.
  25. M Iantorno, H Chen, JA Kim, M Tesauro, D Lauro, C Cardillo, MJ Quon: Ghrelin has Novel Vascular Actions that Mimic Only PI 3-kinase-dependent Insulin-stimulated Production of Nitric Oxide (NO) but Not MAP-kinase-dependent Insulin-stimulated Secretion of ET-1 From Endothelial Cells.  Am J Physiol Endocrinol Metab (2007) 292, 756-764.
  26. MA Potenza, FL Marasciulo, M Tarquinio, E Tiravanti, G Colantuono, A Federici, JA Kim, MJ Quon, and M Montagnani: Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Blood Pressure, Improves Insulin sensitivity, and Protects Against Myocardial Ischemia/Reperfusion (I/R) Injury in Spontaneously Hypertensive Rats (SHR). :Am J Physiol Endocrinol Metab (2007) 292,1378-1387
  27. SH Han, MJ Quon, JA Kim, KK Koh: Adiponectin and cardiovascular disease: response to therapeutic interventions. J. Am. Coll. Cardiol. (2007) 49, 531-538
  28. JA Kim, M Montangnani, G Formoso, Y Li, and MJ Quon: Epigallocatechin gallate (EGCG), a greentea polyphenol, mediates NO-dependent vasodilation using signaling pathway in vascular endothelium involving Fyn, PI 3-kinase, Akt, and eNOS : J Biol Chem (2007)282,13736-13745.
  29. KK Koh, MJ Quon, SJ Lee, SH Han, JY Ahn, JA Kim, Y Lee, E.K Shin: Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension. Diabetes care, (2007) 30,1605-1607
  30. KK Koh, MJ Quon, SH Han, JY Ahn, JA Kim, Y Lee, EK Shin: Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and cardesartan in hypertensive patients. Eur Heart J. (2007) 28,1440-1447.
  31. S Lee, EG Lynn, JA Kim, MJ Quon: Protein kinase C-{zeta} phosphorylates insulin receptor substrate-1, -3, and -4, but not -2: isoform specific determinants of specificity in insulin signaling. Endocrinology, (2008) 149, 2451-8.
  32. JA Kim, Y Wei, JR Sowers: Role of mitochondrial dysfunction in insulin resistance: Cir. Res, (2008) 29, 401-14.
  33. JA Kim: Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial dysfunction: Endocrine, Metabolic & Immune Disorders - Drug Targets (2008) 8, 82-88
  34. CE Reiter, JA Kim, MJ Quon: The green tea polyphenol EGCG reduces ET-1 expression and secretion in vascular endothelial cells: roles for AMPK, Akt, and FOXO1: Endocrinology (2010) 151(1), 103-14
  35. X Zhou, L Ma, J Habibi, A Whaley-Connell, MR Haydon, RD Tilmon, AN Brown, JA Kim, VG Demarco, Sowers JR: Nebivolol Improves Diastolic Dysfunction and Myocardial Remodeling Through Reductions in Oxidative Stress in the Zucker Obese Rat: Hypertension (2010) 55(4), 880-8
  36. S Rizza, R Muniyappa, M Iantorno, JA Kim, H Chen, P Pullikotil, M Tesauro, D Lauro, C Cardillo, MJ Quon: The Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells to Improve Endothelial Function and Reduce Inflammatory Markers in Patients with Metabolic Syndrome: The Journal of Clinical Endocrinology and Metabolism (2011) 96(5), 782-92
  37. JA Kim*, HJ Jang, LA Martinez-Lemus, JR Sowers; Prolonged Activation Of mTOR/p70 S6 Kinase by Angiotensin II Inhibits Insulin Stimulated Endothelial Nitric Oxide Synthas: Am J Physiol Endocrinol Metab (2012) 302(2), E201-8, PMID 22028412 PMCID: PMC3340897 (*Corresponding Author)
  38. JA Kim, M Nunez, BL Laskowski, JJ Chhun, JK Eleid, MJ Quon, and TS Tsao; Extracellular conversion of adiponectin hexamers to trimers: Biosci Rep (2012) 32(6), 641-52, PMID 22973892
  39. JA Kim, M Montagnani, S Chandraskran, MJ Quon; Role of lipotoxicity in endothelial dysfunction: Heart Fail Clin (2012) 8(4), 589-607 PMID 22999242
  40. HJ Jang, HS Kim, D Hwang, MJ Quon,  JA Kim;Toll like receptor 2 mediates high fat diet-induced impairment of vasodilator actions of insulin: Am J Physiol Endocrionol Metab (2013) 304(10), E1077-88PMID 23531618
  41. HS Kim, V Montana, HJ Jang, V Parpura, and JA Kim; Epigallocatechin-gallate (EGCG) stimulates autophagy in vascular endothelial cells: A potential role for reducing lipid accumulation: J Biol Chem (2013)288(31), 22693-705 PMID23754277
  42. HJ Jang, SD Ridgeway, JA Kim; Effects of the Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) on High Fat Diet-Induced Insulin Resistance and Endothelial Dysfunction: Am J Physiol Endocrionol Metab (2013) 305(12): E1444-51 PMID 24148349 PMCID: PMC3882381
  43. HS Kim, MJ Quon, JA Kim; New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate: Redox Biology (2014) 2:187-195
  44. DJ Lim, A Andukuri, JB Vines, P Hwang, SM Rahman, JA Kim, A Shalev, JA Corbett, and HW Jun; Enhanced MIN6 Β-Cell Survival And Function On A Nitric Oxide Releasing Peptide Amphiphile Nanomatrix: International Journal of Nanomedicine, (2014)9:13-21
  45. MA Keske, HLH Ng, D Premilovac, S Rattigan, JA Kim, K Munir, P Yang, and MJ. Quon; Vascular and Metabolic Actions of the Green Tea Polyphenol EGCG: Current Medicinal Chemistry, (2015) 22:59-69
  46. JA Kim, HJ Jang, DH Hwang; Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin: Am J Physiol Endocrionol Metab (2015) 309(9): E767-76 PMID 26522062 PMCID: PMC4628943
  47. GC Alexander, JB Vines, P Hwang, T Ki, JA Kim, BC Brott, YS Yoon, HW Jun; Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. : ACS applied material & interfaces (2016) 8(8) 5178-87 PMID 26849167