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Jayme Elizabeth Locke, M.D., MPH, FACS

Jayme Elizabeth Locke, M.D., MPH, FACS
 
Associate Professor
Department of Surgery
Division of Transplant Surgery
Lyons Harrison Research Building
Room 748
Phone: 205-934-2131
E-mail: jlocke@uabmc.edu

Dr. Locke is an abdominal transplant surgeon that specializes in innovative strategies for the transplantation of incompatible organs, disparities in access to and outcomes after solid organ transplantation, and transplantation of HIV-infected end-stage patients.  Dr. Locke completed an undergraduate degree in biology and chemistry at Duke University and her medical degree at East Carolina University prior to matriculating to Johns Hopkins Hospital where she received training in general surgery and multi-visceral abdominal transplantation.  Dr. Locke completed her Master of Public Health degree with an emphasis in biostatistics and epidemiology at the Johns Hopkins Bloomberg School of Public Health.

Her research interests include complex statistical analysis and modeling of transplant outcomes and behavioral research focused on health disparities.  She has authored 63 articles in peer-reviewed journals and 12 book chapters, and is an NIH-funded investigator. In addition, Dr. Locke is an Associate Editor for Transplantation, and serves as a reviewer for several other leading journals, including the Archives of Surgery, American Journal of Transplantation, American Journal of Kidney Diseases, Annals of Surgery, and the Journal of the American Society of Nephrology. She is also a member of the American Society of Transplantation (AST), American Society of Transplant Surgeons (ASTS), and American Society of Nephrology (ASN), as well as, a Fellow of the American College of Surgeons (ACS). She currently serves on the Kidney-Pancreas Committee for the AST, and on the Diversity Affairs Committee and PROviding Better Access To Organs (PROACTOR) Task Force for the ASTS. Dr. Locke is the recipient of numerous honors and has most recently received the ASTS 2013 Winter Symposium Top Ten Abstract Award, ATC 2013 Young Investigator Award, ASTS 2014 Young Investigator Award, and was named Top 40 Under 40 by the Birmingham Business Journal and AL.com’s 2015 Women Who Shape the State.

Dr. Locke is currently an Associate Professor of Surgery at the University of Alabama at Birmingham, and serves as the Director of the Incompatible Kidney Transplant and Kidney Paired Donation Programs and the Comprehensive Transplant Institute’s Outcomes Research Center.  

Education:

  1. BS - Duke University (1998)
  2. MD - East Carolina University School of Medicine (2002)
  3. MPH - Johns Hopkins University Bloomberg School of Public Health (2007)

Websites:

  1. Estella Floyd (video)
    https://www.uab.edu/kidneychain/item/57-estella-floyd
  2. Colts Rookie Purifoy's Dream: NFL & Healthy Mother (video)
    http://www.colts.com/videos/videos/Colts-Rookie-Purifoys-Dream-NFL--Healthy-Mother/c297f6ef-2762-4cd2-8ae4-ecda46083ee6
  3. UAB Medicine - UAB Kidney Chain (webpage) 
    http://www.uab.edu/kidneychain/
  4. UAB Medicine – UAB Kidney Chain (Facebook)
    https://www.facebook.com/uabkidneychain/
  5. National Public Radio (NPR) – Kidney Chain Links Record Number of Donors and Needing Patients
    http://www.wbhm.org/News/2014/kidneychain
  6. Nightline, ABC News, July 3, 2014 (video) - “Strangers give a kidney so loved ones can receive a kidney”
    http://abcnews.go.com/Nightline/video/strangers-give-kidney-loved-receive-kidney-27229556
  7. Nightline, ABC News, July 3, 2014 (article) - “Strangers Donate Kidneys to Keep Country’s Longest Donor Chain Going”
    http://abcnews.go.com/Health/strangers-donate-kidneys-countrys-longest-donor-chain/story?id=24385817
  8. All videos for UAB Medicine – MD Learning Channel (videos)
    https://www.uabmedicine.org/web/medicalprofessionals/md-learning-channel/transplant-services
  9. UAB Center for Clinical and Translational Science – Why Get an MPH or MSPH?
    https://youtu.be/j8fOmUDNMwY

Publications:

  1. Donnelly JP, Wang HE, Locke JE, Mannon RB, Safford MM, Baddley JW. Hospital-onset Clostridium difficile infection among solid organ transplant recipients. American Journal of Transplantation, 2015; 15(11): 2970-2977. PMID: 26484839
     
  2. Locke JE, Durand C, Reed RD, MacLennan PA, Mehta S, Massie A, Nellore A, DuBay D, Segev DL. Long-term outcomes after liver transplantation among human immunodeficiency virus infected recipients. Transplantation, 2015; [Epub ahead of print]. PMID 26177090
     
  3. Locke JE, Reed RD, Mehta SG, Durand C, Mannon RB, MacLennan PA, Shelton B, Martin MY, Qu H, Shewchuk R, Segev DL. Center-level experience and kidney transplant outcomes in HIV-infected recipients. American Journal of Transplantation, 2015; 15(8): 2096-2104. PMID: 25773499
     
  4. Locke JE, Mehta S, Reed RD, MacLennan PA, Massie A, Nellore A, Durand C, Segev DL. A national study of outcomes among HIV-infected kidney transplant recipients. Journal of the American Society of Nephrology, 2015; 26(9): 2222-2229. PMID: 25791727
     
  5. Locke JE, Qu H, Shewchuk R, Mannon RB, Gaston R, Segev DL, Mannon EC, Martin MY. Identification of strategies to facilitate organ donation among African Americans using the nominal group technique. Clinical Journal of the American Society of Nephrology, 2015; 10(2): 286-93. PMID: 25635038
     
  6. DuBay DA, MacLennan PA, Reed RD, Fouad M, Martin M, Meeks CB, Taylor G, Kilgore M, Tankersley M, Gray SH, White JA, Eckhoff DE, Locke JE. The impact of proposed changes in liver allocation policy on cold ischemia times and organ transportation costs. American Journal of Transplantation, 2015; 15(2): 541-546. PMID: 25612501
     
  7. Orandi B, Zachary AA, Dagher N, Bagnasco S, Garonzik-Wang J, Arendonk K, Gupta N, Lonze B, Alachkar N, Kraus E, Desai N, Locke JE, Racusen L, Segev DL, Montgomery RA. Eculizumab and splenectomy as salvage therapy for severe antibody mediated rejection following HLA incompatible kidney transplantation. Transplantation, 2014; 98(8): 857-863. PMID: 25121475
     
  8. Locke JE. To whom goes the kidney? Liver Transplantation, 2014, 20(9): 1017-1018. PMID: 25044428
     
  9. Dubay DA, Redden DT, Bryant MK, Dorn DP, Fouad MN, Gray SH, White JA, Locke JE, Meeks CB, Taylor GC, Kilgore ML, Eckhoff DE. Resource utilization associated with procurement of transplantable organs from donors that do not meet OPTN eligible death criteria. Transplantation, 2014; 97(10): 1043-1048. PMID: 24503760
     
  10. Locke JE and Segev DL. Is there a role for detection of complement binding antibodies in kidney transplantation? American Journal of Kidney Disease, 2014; 63(4): 558-560. PMID: 24480655
     
  11. Locke JE, James N, Mannon RB, Mehta SG, Pappas PG, Baddley JW, Desai NM, Montgomery RA, and Segev DL. Immunosuppression regimen and the risk of acute rejection in HIV-infected kidney transplant recipients. Transplantation, 2014; 97(4): 446-450. PMID: 24162248
     
  12. Glueckert LN, Redden D, Thompson M, Haque A, Gray SH, Locke JE, Eckhoff DE, Fouad M, and DuBay DA. What happens to liver transplant outcomes when the uninsured become insured? Am J Transplant, 2013; 13(6): 1533-1540. PMID: 23659668
     
  13. Lonze BE, Holzer HT, Knabel MK, Locke JE, DiCamillo GA, Karhadkar SS, Montgomery RA, Sun Z, Warrant DS, Cameron AM. In vitro and ex vivo delivery of short hairpin RNAs for control of hepatitis C viral transcript expression. Archives of Surgery, 2012; 147(4): 384-387. PMID: 22508787
     
  14. Dierberg KL, Marr KA, Subramanian A, Nace H, Desai N, Locke JE, Zang S, Diaz J, Chamberlain C, Neofytos D. Donor-derived organ transplant transmission of coccidioidomycosis. Clinical Infect Dis, 2011; 14(3): 300-304. PMID: 22176496
     
  15. Van Arendonk K, James NT, Locke JE, Montgomery RA, Colombani PM, Segev DL. Increase in late graft loss among pediatric recipients of DCD kidneys. CJASN, 2011; 6(11): 2705-2711. PMID: 21940839
     
  16. Lonze BL, Dagher NN, Liu M, Kucirka LM, Simpkins CE, Locke JE, Desai NM, Cameron AL, Montgomery RA, Segev DL, Singer AL. Outcomes of Renal Transplants from CDC High-Risk Donors with prospective recipient viral testing: a single center experience. Archives of Surgery, 2011; 146(11): 1261-1266. PMID: 22106317
     
  17. Montgomery RA, Lonze BE, King K, Kraus E, Kucirka L, Locke JE, Warren DS, Simpkins CE, Dagher NN, Singer AL, Zachary AA, Segev DL. Desensitization in HLA-incompatible kidney recipients and survival. New Engl J Med, 2011; 365(4): 318-326. PMID: 21793744
     
  18. Mark AL, Sun Z, Warren DS, Lonze BE, Knabel MK, Williams GM, Locke JE, Montgomery RA, Cameron AM. Stem cell mobilization is life saving in an animal model of acute liver injury. Ann Surg, 2010; 252(4): 591-596. PMID: 20881764
     
  19. Lonze BE, Dagher NN, Simpkins CE, Locke JE, Singer AL, Segev DL, Zachary AA, Montgomery RA. Eculizumab, bortezomib and kidney paired donation facilitate transplantation in a highly sensitized patient without vascular access. Am J Transplant, 2010; 10(9): 2154-2160. PMID: 20636451
     
  20. Zachary AA, Montgomery RA, Locke JE, Leffell MS. Proinflammatory events and HLA antibodies. Am J Transplant, 2010; 10(4): 956. PMID: 20148814
     
  21. Allen G, Simpkins CE, Segev D, Warren D, King K, Taube J, Locke JE, Baldwin W, Haas M, Chivukula R, Montgomery RA. Rapid accommodation of an A1 renal allograft after preconditioning for ABO-incompatible transplantation. Contrib Nephrol. 2009;162:35-46. PMID: 19001812
     
  22. Stewart ZA, Locke JE, Segev DL, Cohen C, Singer AL, Montgomery RA, Maley WR, Cameron WR. Hepatic artery thrombosis after liver transplantation is associated with utilization of older donors. Liver Transplant. 2009; 15(12): 1688-1695. PMID: 19938120
     
  23. Melancon JK, Kucirka LM, Boulware LE, Powe NR, Locke JE, Montgomery RA, Segev DL. Impact of Medicare coverage on disparities in access to simultaneous pancreas and kidney transplantation. Am J Transplant. 2009; 9(12): 2785-2791. PMID: 19845587
     
  24. Locke JE, Zachary AA, Warren DS, Segev DL, Houp JA, Montgomery RA, Leffell MS. Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody. Am J Transplant. 2009; 9(9): 2136-2139. PMID: 19663896
     
  25. Stewart ZA, Locke JE, Montgomery RA, Singer AL, Cameron AM, Segev DL. ABO-incompatible deceased donor liver transplantation in the United States: a national registry analysis. Liver Transplant. 2009; 15(8): 883-893. PMID: 19642117
     
  26. Montgomery RA, Locke JE, King KE, Segev DL, Warren DS, Kraus ES, Cooper M, Simpkins CE, Singer AL, Stewart ZA, Melancon JK, Ratner L, Zachary AA, Haas M. ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation. 2009; 87(8): 1246-1255. PMID: 19384174
     
  27. Singer AL, Locke JE, Stewart ZA, Hamilton JP, Scudiere JR, Anders RA, Maley WR, Thuluvath PJ, Brodsky RA, Cameron AM. Successful liver transplantation for Budd-Chiari Syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab. Liver Transplant. 2009; 15(5): 540-543. PMID: 19399743
     
  28. Locke JE, Montgomery RA, Warren DS, Subramanian A, Segev DL. Renal transplantation in HIV-positive recipients: long-term outcomes and risk factors for graft loss. Archives of Surgery. 2009; 144(1): 83-86. PMID: 19153330
     
  29. Locke JE, Singer AL, Segev DL, Haas M, Hillel AT, King KE, Kraus E, Lees LM, Melancon JK, Stewart ZA, Warren DS, Zachary AA, Montgomery RA. The use of antibody to complement protein C5 for salvage treatment of severe antibody mediated rejection. Am J Transplant. 2009; 9(1): 231-235. PMID: 18976298
     
  30. Sun Z, Zhang X, Locke JE, Zheng Q, Tachibana S, Diehl AM, Williams G. Recruitment of host progenitor cells in rat liver transplants. Hepatology. 2009; 49(2): 587-597. PMID: 18972402
     
  31. Haas M, Segev DL, Racusen LC, Bagnasco SM, Locke JE, Warren DS, Simpkins CE, Lepley D, King KE, Kraus ES, Montgomery RA. C4d deposition without histologic changes of rejection correlates with reduced scarring after 1-year in ABO-incompatible renal allografts. J Am Soc Nephrol. 2009; 20(1): 197-204. PMID: 18776120
     
  32. Segev DL, Thompson R, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Prolonged Waiting Times for Liver Transplantation in Obese Patients. Annals of Surgery. 2008; 248(5): 863-870. PMID: 18948816
     
  33. Locke JE, Warren DS, Dominici F, Cameron AM, Leffell MS, McRann DA, Melancon JK, Segev DL, Simpkins CE, Singer AL, Zachary AA, Montgomery RA. The influence of donor ethnicity on outcomes following deceased donor kidney transplantation in black recipients. J Am Soc Nephrol. 2008; 19(10): 2011-2019. PMID: 18650478
     
  34. Locke JE, Sun Z, Warren DS, Sheets TP, Holzer H, Shamblott MJ, Montgomery RA, Cameron AM. Generation of humanized animal livers using stem cell transplant. Annals of Surgery. 2008; 248(3): 487-493. PMID: 18791369
     
  35. Locke JE, Warren DS, Singer AL, Segev DL, Simpkins CE, Maley WR, Montgomery RA, Danovitch G, Cameron AM. Declining outcomes in simultaneous liver kidney transplantation in the MELD era: ineffective utilization of renal allografts. Transplantation. 2008; 85(7): 935-942. PMID: 18408571
     
  36. Segev DL, Kucirka LM, Nguyen GC, Cameron AM, Locke JE, Simpkins CE, Thuluvath PJ, Montgomery RA, Maley WR. Effect modification in liver allografts with prolonged cold ischemic time. Am J Transplant. 2008; 8: 658-666. PMID: 18294162
     
  37. Montgomery RA and Locke JE. ABO-incompatible transplantation: less may be more. Transplantation. 2007; 84(12 Suppl): S8-9. PMID: 18162992
     
  38. Segev DL, Simpkins CE, Thompson RE, Locke JE, Warren DS, Montgomery RA. Obesity impacts access to kidney transplantation. J Am Soc Nephrol. 2007; 19(2): 349-355. PMID: 18094366
     
  39. Segev DL, Maley WR, Simpkins CE, Locke JE, Montgomery RA, Thuluvath PJ. Minimizing risk associated with elderly liver donors by matching to preferred recipients. Hepatology. 2007; 46(6): 1907-1918.
     
  40. Segev DL, Nguyen GC, Locke JE, Simpkins CE, Montgomery RA, Maley WR, Thuluvath PJ. 20 years of liver transplantation for Budd-Chiari Syndrome: a national registry analysis. Liver Transplantation. 2007 13(9): 1285-1294. PMID: 17763380
     
  41. Locke JE, Segev DL, Warren DS, Dominici F, Simpkins CE, Montgomery RA. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant. 2007 7(7): 1797-1807. PMID: 17524076
     
  42. Locke JE, Zachary AA, Haas M, Melancon JK, Warren DS, Simpkins CE, Segev DL, Montgomery RA. The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection. Am J Transplant. 2007; 7(4): 842-846. PMID: 17391127
     
  43. Simpkins CE, Montgomery RA, Hawxby AM, Locke JE, Gentry SE, Warren DS, Segev DL. Cold ischemic time and allograft outcomes in live donor renal transplantation: is live donor organ transport feasible? Am J Transplant. 2007; 7(1): 99-107. PMID: 17227561
     
  44. Lee KW, Simpkins CE, Montgomery RA, Locke JE, Segev DL, Maley WR. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation. 2006; 82(12): 1683-1688. PMID: 17198260
     
  45. Locke JE, Choti MA, Torbenson MS, Horton KM and Molmenti EP. Inflammatory pseudotumor of the liver. Journal of Hepatobiliary and Pancreatic Surgery. 2005; 12: 314-316. PMID: 16133699