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Liou Y. Sun, M.D. Ph.D.

OLiou Y. Sun, PhD
 
Assistant Professor
Department of Biology
University of Alabama at Birmingham
1300 University Blvd., Birmingham, AL 35294
Phone: 205-934--8243
Email: sunlab@uab.edu
Full CV
Web Site

Dr. Sun did his graduate work with Andrzej Bartke at SIUC to understand of the molecular pathway in which the endocrine deficiencies in GH mutant mice lead to delayed aging. He then worked in Richard Miller’s lab at University of Michigan, where he studied the role of stress resistance pathways and their roles in modulating the rate of aging. Dr. Sun is currently an assistant professor in the Department of Biology at the University of Alabama at Birmingham.

Education:

  • MD, Southeast University Medical School, Nanjing (China), Medicine
  • PhD, Southern Illinois University, Carbondale, Molecular, Cellular, and Systemic Physiology

Research Interests:

Our laboratory is exploring the genetic control of aging in mammals and vertebrates
We are studying the endocrine mechanisms and nutritional factors for their effects on longevity and aging.

  1. The physiological role of the somatotropic axis in the control of aging in mammals and vertebrates.
  2. The dietary factors on aging: calorie restriction vs. methionine restriction.
  3. Interventions of age-related diseases. 

Publications:

  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • pre 2011
  1. Hill CM, Arum O, Boparai RK, Wang F, Fang Y, Sun LY, Masternak MM, Bartke A. Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age. Age (Dordr). 2015 Jun;37(3):9765.
     
  2. Do A, Menon V, Zhi X, Gesing A, Wiesenborn DS, Spong A, Sun L, Bartke A, Masternak MM.Thyroxine modifies the effects of growth hormone in Ames dwarf mice. Aging (Albany NY) 2015 Apr;7(4):241-55.
     
  3. Sun LY, Bartke A. Tissue-Specific GHR Knockout Mice: Metabolic Phenotypes. Front Endocrinol 2015 Jan 19; 5:243
     
  1. List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun LY, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014 May;155(5):1793-805.
     
  1. Sun LY*, Spong A, Swindell WR, Fang Y, Hill C, Huber JA, Boehm JD, Westbrook R, Salvatori R, Bartke A. Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. eLife 2013 Oct 29;2:e01098. doi: 10.7554/eLife.01098. * as the corresponding author.
     
  2. Li X, Bartke A, Berryman DE, Funk K, Kopchick JJ, List EO, Sun LY, Miller RA. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E942-50.
     
  3. Bartke A, Sun LY, Longo VD. Somatotropic signaling; trade-offs between growth, reproductive development and longevity 2013 Physiol Rev. 2013 Apr;93(2):571-98
     
  4. Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, Wang F, Javors MA, Chen J, Sun LY, Bartke A. Cell Metab. 2013 Mar 5;17(3):456-62.
     
  5. Bartke A, Westbrook R, Sun LY, Ratajczak M. Links between growth hormone and aging. Endokrynol Pol. 2013;64(1):46-52.
     
  1. Steinbaugh MJ, Sun LY, Bartke A, Miller RA. Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan 2012 Am J Physiol Endocrinol Metab. 2012 Jun 12
     
  2. Swindell WR, Johnston A, Sun LY, Xing X, Fisher GJ, Voorhees JJ, Bulyk ML, Elder JT, Gudjonsson JE. Meta-profiles of gene expression during aging: Limited similarities between mouse and human and an unexpectedly decreased inflammatory signature PLoS One 2012;7(3):e33204.
     
  1. Liu Z, Sun LY Complex roles of Sirtuin 1 in cancer and aging.. Transl Res. 2011 May;157(5):273-5. Epub 2011 Jan 22.
     
  1. Sun LY, Bokov AF, Richardson A, Miller RA. Hepatic response to oxidative injury in longlived Ames dwarf mice. FASEB J. 2010 Sep 8
     
  2. Sun LY, Bartke A. Adult neurogenesis in the hippocampus of long-lived mice during aging. J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):117-25.
     
  3. Sun LY, D'Ercole AJ. Insulin-like growth factor-I stimulates histone H3 and H4 acetylation in the brain in vivo. Endocrinology. 2006 Nov;147(11):5480-90. Epub 2006 Aug 24.
     
  4. Sun LY. Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice. Age (Dordr). 2006 Jun;28(2):181-9. Epub 2006 Jun 13.; Invited review
     
  5. Sun LY, Al-Regaiey K, Masternak MM, Wang J, Bartke A. Local expression of GH and IGF- 1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging. 2005 Jun;26(6):929-37.
     
  6. Sun LY, Evans MS, Hsieh J, Panici J, Bartke A. Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology. 2005 Mar;146(3):1138-44. Epub 2004 Nov 24.
     
  7. Al-Regaiey KA, Masternak MM, Bonkowski M, Sun LY, Bartke A. Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology. 2005 Feb;146(2):851-60. Epub 2004 Oct 21.
     
  8. Masternak MM, Al-Regaiey K, Bonkowski MS, Panici J, Sun LY, Wang J, Przybylski GK, Bartke A. Divergent effects of caloric restriction on gene expression in normal and long-lived mice. J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):784-8.