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Stella Aslibekyan, PhD

Assistant Professor
Department of Epidemiology
RPHB 230J
University of Alabama at Birmingham
Birmingham, AL 35294
Phone: : (205) 975-9108
Fax: (205) 934-8665
E-mail: saslibek@uab.edu
Full CV

I am a cardiovascular epidemiologist with extensive training in statistical genetics and epigenetics. Broadly, my research interests lie in epidemiologic study design, integrating epigenetic data with other –omic and phenotypic data in the context of chronic disease. I have led genome- and epigenome-wide analyses of obesity and related traits in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) as well as in a cohort of Yup’ik individuals. Additionally, I have investigated the role of gene-obesity interactions in mediating drug response in the context of rheumatoid arthritis. Through my membership in the Nutrition and Obesity Research Center, I intend to build collaborations to facilitate functional validation and replication studies to follow-up my initial genetic and epigenetic findings.

Education:

  • Doctor of Philosophy in Epidemiology, May 2011, Brown University, Department of Community Health, Providence, RI, USA
  • Master of Science in Epidemiology, May 2008, Harvard School of Public Health, Boston, MA, USA
  • Bachelor of Arts (Honors) in Human Biology, June 2005, Stanford University, Stanford, CA, USA

Publication:

  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • pre 2012
  1. Aslibekyan S, Laufer VA, Arnett DK, Bridges SL. Editorial: A novel genetic association with systemic sclerosis: the utility of whole exome sequencing in autoimmune disease. Arthritis Rheumatol 2016; Jan;68(1):27-30. [doi: 10.1002/art.39451] [PMID: 26473989]
     
  2. Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W, Wang L, Biggs ML, Chen YI, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L, Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B, Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies Stella Aslibekyan and a methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr 2016; in press.
     
  3. Das M, Sha J, Hidalgo B, Aslibekyan S, Do AN, Zhi D, Sun D, Zhang T, Li S, Chen W, Srinivasan SR, Tiwari HK, Absher D, Ordovas JM, Berenson GS, Arnett DK, Irvin MR. Association of DNA methylation at CPT1A locus with metabolic syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS ONE 2016; 11:e0145789.
     
  4. Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovas JM. Clock genes explain a large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature. Am J Hypertens 2016; 29:132-40.
     
  1. Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C, Irvin MR, Fornage M, Hidalgo B, Lin LA, Thibeault KS, Bressler J, Tsai MY, Grove ML, Hopkins PN, Boerwinkle E, Borecki IB, Ordovas JM, Levy D, Tiwari HK, Absher DM, Arnett DK. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity 2015; 23:1493-501.
     
  2. Aslibekyan S, Claas SA, Arnett DK. Clinical applications of epigenetics in cardiovascular disease: the long road ahead. Transl Res 2015; 165:143-53.
     
  3. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA, Tsai MY, Borecki IB, Kabagambe EK, Ordovas JM, Absher DM, Arnett DK. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Mol Nutr Food Res 2015; in press.
     
  4. Bajaj NS†, Kalra R, Aggarwal H, Ather S, Gaba S, Arora G, McGiffin DC, Ahmed M, Aslibekyan S, Arora P. Comparison of approaches to revascularization in patients with multivessel coronary artery disease presenting with ST-segment elevation myocardial infarction: meta-analyses of randomized controlled trials. J Am Heart Assoc 2015; 4:pii:e002540.
     
  5. Das M, Irvin R, Sha J, Aslibekyan S, Hidalgo B, Perry RT, Zhi D, Tiwari HK, Absher D, Ordovas JM, Arnett DK. Lipid changes due to fenofibrate treatment are not associated with changes in DNA methylation patterns in the GOLDN study. Front Genet 2015;6:304.
     
  6. Wojczynski MK, Parnell LD, Pollin TI, Lai CQ, Feitosa MF, O’Connell JR, Frazier-Wood AC, Gibson Q, Aslibekyan S, Ryan KA, Province MA, Tiwari HK, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN). Metabolism 2015; 64:1359-71.
     
  7. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet Genomics 2015; 25:511-4.
     
  8. Demerath E, Guan W, Grove M, Aslibekyan S, Mendelson M, Zhou YH, Hedman A, Sandling J, Lin LA, Irvin M, Zhi D, Deloukas P, Liang L, Liu C, Bressler J, Spector T, North K, Li Y, Absher D, Levy D, Arnett D, Fornage M, Pankow J, Boerwinkle E. Epigenome-wide association study (EWAS) of BMI, BMI change, and waist circumference in African American adults identifies multiple replicated loci. Hum Mol Genet 2015; 24:4464-79.
     
  9. Tran NT†, Aslibekyan S, Tiwari HK, Zhi D, Sung YJ, Rao DC, Hunt SC, Broeckel U, Arnett DK, Judd SE, Muntner P, Kent ST, Irvin R. PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies. Front Genet 2015; 6:136.
     
  10. Vaughn LK, Wiener HW, Aslibekyan S, Allison DB, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Lemas DJ, Boyer BB, Tiwari HK. Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism 2015; 64:689-97.
     
  11. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA, Tsai MY, Borecki IB, Kabagambe EK, Berciano S, Ordovas JM, Arnett DK. Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study. Aging Cell 2015; 14:49-59.
     
  1. Aslibekyan S, Wiener HW, Wu G, Zhi D, Shrestha S, de los Campos G, Vazquez AI. Estimating proportions of explained variance: a comparison of whole genome subsets. BMC Proc 2014; Suppl 1 Genetic Analysis Workshop 18:S102.
     
  2. Aslibekyan S, Dashti HS, Tanaka T, Sha J, Ferrucci L, Zhi D, Bandinelli S, Borecki IB, Absher DM, Arnett DK, Ordovas JM. PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population. Chronobiol Int 2014; 31:1034-40. *Contributed equally as first authors
     
  3. Aslibekyan S, Almeida M, Tintle N. Pathway analysis approaches for rare and common variants: insights from genetic analysis workshop 18. Genet Epidemiol 2014; Suppl 1:S86-91.
     
  4. Aslibekyan S, Wiener HW, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Absher DM, Tiwari HK, Boyer BB. DNA methylation patterns are associated with n-3 fatty acid intake in Yup’ik people. J Nutr 2014; 144:425-30.
     
  5. Aslibekyan S*, Brown EB*, Reynolds RJ*, Redden DT, Morgan SL, Baggott JE, Sha J, Moreland LW, O’Dell JR, Curtis JR, Mikuls TR, Bridges SL, Arnett DK. Genetic variants associated with methotrexate efficacy and toxicity in early rheumatoid arthritis: results from the Treatment of Early Aggressive Rheumatoid Arthritis (TEAR) Trial. Pharmacogenomics J 2014; 14:48-53. *Contributed equally as first authors
     
  6. Aslibekyan S, Sha J, Redden DT, Moreland LW, O’Dell JR, Curtis JR, Mikuls TR, Hughes LB, Reynolds RJ, Danila MI, Bridges SL, Arnett DK. Gene-BMI interactions are associated with methotrexate toxicity in rheumatoid arthritis. Ann Rheum Dis 2014: 73; 785-6.
     
  7. Irvin MR, Aslibekyan S, Hidalgo B, Arnett D. CPT1A: the future of heart disease detection and personalized medicine? Clin Lipidol 2014; 9:9-12.
     
  8. Liu X, Liu J, Liang S, Schluter A, Fourcade S, Aslibekyan S, Pujol A, Graf GA. ABCD2 alters PPARa signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesity. Mol Pharmacol 2014; 86:505-13.
     
  9. Irvin M, Zhi D, Joehanes R, Mendelson M, Aslibekyan S, Claas S, Thibeault K, Patel N, Day K, Jones LW, Liang L, Chen B, Yao C, Tiwari H, Ordovas J, Levy D, Absher D, Arnett D. Epigenome-wide associations study of fasting blood lipids in the Genetics of Lipid Lowering Drugs and Diet Network study. Circulation 2014; 130:565-72.
     
  10. Frazier-Wood AC, Aslibekyan S, Absher DM, Hopkins PN, Sha J, Tsai MY, Tiwari HK, Waite L, Zhi D, Arnett DK. Methylation at CPT1A locus is associated with lipoprotein subfraction profiles. J Lipid Res 2014; 55:1324-30.
     
  11. Irvin MR, Zhi D, Aslibekyan S, Claas SA, Absher DM, Ordovas JM, Tiwari HK, Watkins SM, Arnett DK. Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study. PLoS ONE 2014; 9:e99509.
     
  12. Hidalgo B, Irvin M, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari H, Kabagambe E, Ordovas J, Arnett D. Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in GOLDN. Diabetes 2014; 63:801-7
     
  1. Aslibekyan S, Vaughan LK, Wiener HW, Lemas DJ, Klimentidis YC, Havel PJ, Stanhope KL, O’Brien DM, Hopkins SE, Boyer BB, Tiwari HK. Evidence for novel genetic loci associated with metabolic traits in Yup’ik people. Am J Hum Biol 2013; 25:673-80.
     
  2. Aslibekyan S, Claas SA, Arnett DK. Establishing validity of pharmacogenetic findings: from replication to triangulation. Circ Cardiovasc Genet 2013; 6:409-12.
     
  3. Aslibekyan S, Straka RJ, Irvin MR, Claas SA, Arnett DK. Pharmacogenetics of HDL-C therapies. Exp Rev Cardiovasc Ther 2013; 11:355-64.
     
  4. Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. Nutr Metab Cardiovasc Dis 2013; 23:987-94.
     
  5. Smith CE, Tucker KL, Arnett DK, Noel SE, Corella D, Borecki IB, Feitosa MF, Aslibekyan S, Parnell LD, Lai CQ, Lee YC, Ordovas JM. Apolipoprotein A-II polymorphism interacts with dairy foods to influence body weight in two US populations. J Nutr 2013; 143:1865-71.
     
  6. Zhi D, Aslibekyan S, Irvin MR, Claas SA, Borecki IB, Ordovas JM, Absher DM, Arnett DK. CpG-changing SNPs modulate genome-epigenome interaction. Epigenetics 2013; 8:802-6.
     
  7. Frazier-Wood AC, Manichaikul A, Aslibekyan S, Borecki IB, Goff DC, Hopkins PN, Lai CQ, Ordovas JM, Post WS, Rich SS, Sale MM, Siscovick DS, Straka RJ, Tiwari HK, Tsai MY, Rotter JI, Arnett DK. Genetic variants associated with VLDL, LDL, and HDL particle size differ with ethnicity. Hum Genet 2013; 132:405-13.
     
  1. Aslibekyan S, Goodarzi MO, Frazier-Wood AC, Yan X, Irvin MR, Kim E, Tiwari HK, Guo X, Straka RJ, Taylor KD, Tsai MY, Hopkins PN, Korenman SG, Borecki IB, Chen YD, Ordovas JM, Rotter JI, Arnett DK. Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate. PLoS ONE 2012; 7:e48663.
     
  2. Aslibekyan S, Jensen MK, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Deka R, Rimm EB, Baylin A. Fatty acid desaturase polymorphisms and the risk of nonfatal myocardial infarction in the Costa Rica Study. Front Genet 2012; 3:72.
     
  3. Aslibekyan S, Jensen MK, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Deka R, Rimm EB, Baylin A. Fatty acid elongase gene variants are not associated with serum blood lipids, inflammation, or the risk of nonfatal myocardial infarction. Eur J Clin Nutr 2012; 66:353-9.
     
  4. Aslibekyan S, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Shen J, Lai CQ, Ordovas JM, Arnett DK. A genome-wide association study of inflammatory markers in response to fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN). Pharmacogenet Genomics 2012; 22:191-7.
     
  5. Aslibekyan S, Campos H, Baylin A. Biomarkers of dairy intake and the risk of heart disease. Nutr Metab Cardiovasc Dis 2012; 22:1039-45.
     
  6. Frazier-Wood AC, Aslibekyan S, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Genome-wide association study of lipoprotein diameter response to fenofibrate. Pharmacogenet Genomics 2012; 22:750-7.
  1. Aslibekyan S, Campos H, Loucks EB, Linkletter CD, Ordovas JM, Baylin A. Development of a new cardiovascular risk score for use in low- and middle-income countries. J Nutr 2011; 141:1375-80.
     
  2. Aslibekyan S, Levitan EB, Mittleman MA. Prevalent cocaine use and myocardial infarction. Am J Cardiol 2008; 102:966-9.