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James M. Shikany, DrPH

James M. Shikany, DrPH
Department of Medicine
Division of Preventive Medicine
Medical Towers 619
1717 11th Avenue South
Birmingham, Alabama 35205
Phone: 205-975-7989
Fax: 205-934-7959
Web Site

Research Interests

Dr. Shikany’s research interests include the association between diet and the epidemiology and prevention of chronic disease (including cancer and cardiovascular disease), with special emphasis on antioxidants, dietary fats, glycemic index/glycemic load, and novel dietary assessment methodologies.

He is a Scientist in the Diabetes Research and Training Center, Center for Aging, Center for Cardiovascular Biology, and Center for Exercise Medicine, and Associate Scientist in the Nutrition Obesity Research Center, Comprehensive Cancer Center, and Minority Health & Research Center at UAB.

Current Research Projects

N01HC95095 (Shikany) 02/01/1989 – 06/30/2013
Longitudinal Studies of Coronary Heart Disease Risk Factors in Young Adults (CARDIA) - Coordinating Center
Coordinating Center for the four-center CARDIA Study. Goal of the CARDIA Study is to assess coronary artery risk factors in healthy 18-30 year olds. Dr. Shikany serves as the principal investigator of the study’s coordinating center.

U01AR45632 (Shikany) 09/30/1999 – 07/31/2012
Osteoporotic Fractures in Men (MrOS) Renewal - Birmingham
The primary goal of this study is to determine the extent to which fracture risk in older men is related to bone mass, bone geometry, lifestyle factors, biochemical measures, fall propensity, and other variables. Dr. Shikany serves as principal investigator of the Birmingham site.

R01HL053560 (Jacobs) 04/01/2010 – 05/31/2012
(Shikany, subcontract PI)
NIH (NHLBI)/University of Minnesota
Epidemiology Oxidative Stress and Early Atherosclerosis 
This ancillary study renewal will collect blood and urine at the CARDIA year 25 exam and conduct biochemical assays related to antioxidants and oxidative damage. Through these measures, we will continue to evaluate the associations of antioxidants and oxidative damage with early/subclinical coronary heart disease and offer possible new means of prevention. Dr. Shikany serves as the principal investigator of the Birmingham field center.

R01DK084997 (Van Den Eeden) 09/15/2010 – 08/31/2014
(Shikany, subcontract PI)
NIH (NIDDK)/Kaiser Foundation Research Institute 
Adult Life Predictors of Genitourinary Disorders
The overall objective of this study is to examine how longitudinal changes in selected factors are related to benign genitourinary conditions, including modifiable factors (obesity, physical activity, tobacco and alcohol use, exogenous hormone use, and diet), co-morbidities (diabetes/glucose metabolism, and cardiovascular conditions), and biomarkers (inflammatory markers, lipid levels, endogenous hormone and binding protein levels). We will examine how these factors are related to new onset or change in benign genitourinary conditions. Dr. Shikany serves as the principal investigator of the study’s coordinating center.

R01HL098445 (Carr) 08/01/2010 – 03/31/2015
NIH/Wake Forest University Health Sciences 
Longitudinal Changes in Pericardial Adiposity and Subclincal Atherosclerosis
The broad long-term objectives of this study are to reduce the burden of CVD in the US population through increased knowledge of central adiposity and subclinical coronary artery disease that can be translated into prevention activities, development of diagnostic test and monitoring of therapies. The specific aims of this study are focused on elucidating the role of pericardial adipose tissue and its change over 10 years in the development of subclinical atherosclerosis, including specific plaque morphology associated with culprit lesions of myocardial infarction, in middle-aged adults, independent of other risk factors and measures of body size. Dr. Shikany serves as the principal investigator of the study’s coordinating center.

Educational Background

  • University of California, Los Angeles, DrPH, 1994
  • University of California, Los Angeles, MS, Public Health, 1990
  • Medical University of South Carolina, Physician Assistant, 1982
  • University of California, Davis, BS, Psychology, 1978

Professional Activities

  • Member, American Society for Nutrition; 2005-present
  • Fellow member, American Academy of Physician Assistants; 1983-present

Selected Recent Publications

  • Shikany JM, Phadke RP, Redden DT, Gower BA. Effects of low- and high-glycemic index/glycemic load diets on coronary heart disease risk factors in overweight/obese men. Metabolism. 2009;58:1793-801. PMID: 19631353;
  • Belin RJ, Greenland P, Allison M, Martin L, Shikany JM, Larson J, Tinker L, Howard BV, Lloyd-Jones D, Van Horn L. Diet quality and the risk of cardiovascular disease: the Women’s Health Initiative (WHI). Am J Clin Nutr. 2011;94:49-57.
  • Cauley JA, Danielson ME, Boudreau R, Barbour KE, Horwitz MJ, Bauer DC, Ensrud KE, Manson JE, Wactawski-Wende J, Shikany JM, Jackson RD. Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: the Women’s Health Initiative (WHI). J Bone Miner Res. 2011;26:2378-88.
  • Shikany JM, Redden DT, Neuhouser ML, Chlebowski RT, Rohan TE, Simon MS, Liu S, Lane DS, Tinker L. Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women’s Health Initiative. Nutr Cancer. 2011;63:899-907.
  • Boone-Heinonen J, Gordon-Larsen P, Kiefe CI, Shikany JM, Lewis CE, Popkin BM. Fast food restaurants and food stores: longitudinal associations with diet in young to middle-aged adults: the CARDIA Study. Arch Int Med. 2011;171:1162-70.
  • Halanych JH, Safford MM, Shikany JM, Cuffee Y, Person SD, Scarinci IC, Kiefe CI, Allison JJ. The association between income, education, and experiences of discrimination in older African American and European American patients. Ethn Dis. 2011;21:223-9.
  • Takata Y, Kristal AR, King IB, Song X, Diamond AM, Foster CB, Hutter CM, Hsu L, Duggan DJ, Langer RD, Petrovitch H, Shikany JM, Vaughan TL, Lampe JW, Prentice RL, Peters U. Serum selenium, genetic variation in selenoenzymes, and risk of colorectal cancer: primary analysis from the Women's Health Initiative Observational Study and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20:1822-30.
  • Shikany JM, Desmond R, McCubrey R, Allison DB. Meta-analysis of studies of a specific delivery mode for a modified-carbohydrate diet. J Hum Nutr Diet. 2011;24:525-35.
  • Margolis KL, Wei F, DeBoer IH, Howard BV, Liu S, Manson JE, Mossavar-Rahmani Y, Phillips LS, Shikany JM, Tinker LF; Women’s Health Initiative Investigators. A diet high in low-fat dairy products lowers diabetes risk in postmenopausal women. J Nutr. 2011;141:1969-74.
  • Shikany JM, Thomas AS, McCubrey R, Beasley TM, Allison DB. Randomized controlled trial of chewing gum for weight loss. Obesity (Silver Spring). 2011 Nov 10 (Published electronically ahead of print).


IOTA Chapter, Delta Omega Public Health Honor Society; elected 1992