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Karen L. Gamble, Ph.D.

KAREN L. GAMBLE, Ph.D. Associate Professor
Department of Psychiatry & Behavioral Neurobiology
University of Alabama at Birmingham Medical Center
715 Sparks Center, 1530 3RD Ave S
Birmingham, AL 35294-0017
Phone: (205) 934-4663
Fax: (205) 975-4879
Full CV


Research Interest

The overall goal of the Gamble Laboratory research program is to investigate how the central mammalian clock integrates environmental and molecular signals into robust behavioral and physiological rhythms. Recently, several important studies have implicated circadian clocks in regulating metabolic function. One of the primary projects in our lab is to investigate the role of glycogen synthase kinase 3 (GSK3), an established modulator of insulin sensitivity, in regulation of the circadian clock. Specifically, we plan to define the role of circadian regulation of GSK3 in maintaining energy balance. The results of our research may have important implications for GSK3 in metabolic deficiencies common in metabolic syndrome, environmentally-induced obesity, and aging.


  • 2012
  • 2011
  • 2010
  • 2009
  • Pre 2009
  1. Paul, J.R., Johnson, R.L., Jope, R.S., and Gamble, K.L. (2012). Disruption of circadian rhythmicity and suprachiasmatic action potential frequency in a mouse model with constitutive activation of glycogen synthase kinase-3. Neuroscience, in press.
  2. Zhou, W., Chen, L., Paul, J.R., Yang, S., Li F., Sampson, K., Woodgett, J.R., Beaulieu, J.M., Gamble, K.L., and Li, X. (2012). The Effects of Glycogen Synthase Kinase-3beta in Serotonin Neurons. PloS ONE, in press.
  3. Bray, M.S., Ratcliffe, W.F., Grenett, M.H., Brewer, R.A., Gamble, K.L., and Young, M.E. (2012). Quantitative Analysis of Light-Phase Restricted Feeding Reveals Metabolic Dyssynchrony in Mice. Int J Obesity, in press.
  4. DeAndrade, M.P., Johnson Jr., R.L., Unger, E.L., Zhang, L., van Groen, T., Gamble, K.L., and Li,Y. (2012). Motor restlessness, sleep disturbances, thermal sensory alterations, and elevated serum iron levels in Btbd9 mutant mice. Hum Mol Gen, June 20, epub ahead of print [PMID:22678064]
  5. Jackson, C.R., Ruan, G., Aseem, F., Abey, J., Gamble, K.L., Stanwood, G., Palmiter, R.D., Iuvone, P.M., and McMahon, D.G. (2012). Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci, in press.
  6. Ruan, G., Gamble, K.L., Risner, M., Young, L., and McMahon, D.G. (2012). Divergent Roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators. PLoS ONE, 7(6), e38985.
  7. Dougherty SE, Reeves JL, Lucas EK, Gamble KL, Lesort M, and Cowell RM (2012). Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington Disease. Exp Neurol, 236(1), 171-8.
  8. Besing, R.C., Hablitz, L.M., Paul, J.R., Johnson, R.L., Prosser, R.A., & Gamble, K.L. (2012). NPY-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner. Chronobiol Int, 29(2), 91-102.
  1. Fargason, R.E., Gamble, K.L., Avis, K.T., Besing, R.C., Jackson, C., Cates, M., and May, R.S. (2011). Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD). Psychopharm Bull, 44(2).
  2. Durgan, D.J., Pat, B.M., Laczy, B., Bradley, J.A., Tsai, J., Grenett, M.H., Ratcliffe,W.F., Brewer, R.A., Nagendran, J., Villegas-Montoya, C., Zou, C., Johnson, R.L., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Chatham, J.C., and Young, M.E. (2011). O-GlcNAcylation: A novel post-translational modification linking myocardial metabolism and the cardiomyocyte circadian clock. Journal of Biol Chem, 286(52) 44606-19.
  3. Gamble, K.L., Motsinger-Reif, A.A., Hida, A., Borsetti, H.M., Servick, S.V., Ciarleglio, C.M., Robbins, S., Hicks, J., Carver, K., Hamilton, N., Wells, N., Summar, M.L., McMahon, D.G., and Johnson, C.H. (2011). Shiftwork in nurses: Contribution of phenotypes and genotypes to adaptation. PLoS ONE, 6(4), e18395.
  4. Thompson, B.J., Jessen, T., Henry, L.K., Field, J.R., Gamble, K.L., Gresch, P.J., Carneiro, A.M., Horton, R.E., Chisnell, P.J., Belova, Y., McMahon, D.G., Daws, L.C., & Blakely, R.D. (2011). Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. PNAS, 108(9), 3785-90.
  5. Gamble, K.L.*, Kudo, T., Colwell, C.S., and McMahon, D.G.* (2011). “Gastrin releasing peptide modulates fast delayed rectifier potassium current in Per1-expressing SCN neurons.” J Biol Rhythms, 26(2), 99-106. * Co-corresponding authors.
  1. Durgan, D.J., Tsai, J., Grenett, M.H., Pat, B.M., Ratcliffe,W.F., Villegas-Montoya, C., Garvey, M.E., Nagendran, J., Dyck, J.R.B., Bray, M.S., Gamble, K.L., Gimble, J.M., and Young, M.E. (2010). “Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice.” Chronobiol Int, 185(10), 5796-5805.
  2. Ciarleglio, C.M., Axley, J.C., Strauss, B.R., Gamble, K.L. and McMahon, D.G. (2010). “Perinatal photoperiod imprints the circadian clock.” Nat Neurosci 14(1), 25-7.
  3. Castanon-Cervantes, O., Wu, Mingwei, Ehlen, J.C., Paul, K., Gamble, K.L., Johnson, R.L., Besing, R.C., Menaker, M., Gewirtz, A.T., and Davidson, A.J. (2010). “Disregulation of inflammatory responses by chronic circadian disruption.” J Immunol, 185(10), 5796-805.
  1. Xu, X., Graeff, R., Xie, O., Gamble, K.L., Mori, T., and Johnson, C.H. (2009). Comment on: "The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop." Science, 326 (5950), 230.
  2. Gamble, K.L. and Ciarleglio, C.M. (2009). Ryanodine receptors are regulated by the circadian clock and implicated in gating photic entrainment. J Neurosci, 29(38), 11717-19.
  3. Ciarleglio, C.M, Gamble, K.L., Axley, J.C., Strauss, B.R., Cohen, J., Colwell, C.S., and McMahon, D.G. (2009). Population Encoding by Circadian Clock Neurons Organizes Circadian Behavior. J Neurosci, 29(6), 1670-6.
  1. Ehlen, J. C., Novak, C. M., Karom, M. C., Gamble, K. L. & Albers, H. E. (2008). Interactions of GABAA Receptor Activation and Light on Period mRNA Expression in the Suprachiasmatic Nucleus. J Biol Rhythms 23, 16-25.
  2. Gamble, K.L., Allen, G., Zhou, T.R., and McMahon, D.G. (2007). Gastrin releasing peptide induces Per1 throughout the SCN and phase delays Per2-luc rhythms in a CREB-dependent manner. J Neurosci, 27(44), 12078-87.
  3. Ehlen, J.C., Novak, C.M., Gamble, K.L., Paul, K.N., and Albers, H.E. (2006). GABA-A receptor activation suppresses Period 1 mRNA and Period 2 mRNA in pattern similar to other nonphotic stimuli during the mid-subjective day. Eur J Neurosci, 23(12), 3328-36.
  4. Gamble, K.L., Paul, K.N., Karom, M.C., Tosini, G., and Albers, H.E. (2006). Paradoxical effects of NPY in the suprachiasmatic nucleus. Eur J Neurosci 23(9), 2488-94.
  5. Gamble, K.L., Ehlen, J.C., and Albers, H.E. (2005). Circadian control during the day and night: Role of neuropeptide Y Y5 receptors in the suprachiasmatic nucleus. Brain Res.Bull., 65(6), 513-519.
  6. Paul, K.N., Gamble, K.L., Fukuhara, C., Novak, C.M., Tosini, G., and Albers, H.E. (2004). Tetrodotoxin administration in the suprachiasmatic nucleus prevents NMDA-induced reductions in pineal melatonin without influencing Per1 and Per2 mRNA levels. Eur.J.Neurosci., 19, 2808-2814.
  7. Gamble, K.L., Novak, C.M., and Albers, H.E. (2004). Neuropeptide y and n-methyl-d-aspartic acid interact within the suprachiasmatic nuclei to alter circadian phase. Neuroscience, 126, 559-565.
  8. Gamble, K.L., Novak, C.M., Paul, K.N., and Albers, H.E. (2003) Tetrodotoxin blocks the circadian effects of NMDA during the day but not at night. Neuroreport 14(4), 641-644.