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Orlando Gutierrez, MD, MMSc

Orlando Gutierrez, MD Professor
Hilda B. Anderson Endowed Chair in Nephrology
Department: Medicine
Division of Nephrology
Phone: 205-996-2186
E-mail: ogutierr@uab.edu
Full CV

Dr. Gutiérrez is currently a Professor of Medicine and head of the Section of Epidemiology and Outcomes Research in the Division of Nephrology at the University of Alabama at Birmingham. Using both epidemiologic and patient-oriented clinical research approaches, the primary focus of Dr. Gutiérrez’s group has been elucidating the mechanisms by which disorders of bone and mineral metabolism and nutrition impact outcomes in individuals with chronic kidney disease. He has received detailed training in human physiological studies including a Master’s degree in human clinical investigation from Harvard Medical School. In addition, Dr. Gutiérrez has a track record of publications, including prior feeding studies using physiological end-points, and other high-impact studies that have highlighted the associations of environmental and biological factors with outcomes in the general population and in individuals with CKD. This includes three funded projects that are currently using or have incorporated detailed feeding studies in healthy individuals or individuals with kidney disease (AHA 15SFDRN25620022, AHA 15SFRN2480000, R03 DK095005). This experience positions Dr. Gutiérrez to successfully serve as the principal investigator of this project.

Research/Clinical Interest

Mineral metabolism and outcomes
Using both epidemiological and patient-oriented physiological approaches, Dr. Gutierrez has concentrated his research efforts on the relationships between disturbances in mineral metabolism and clinical outcomes, focusing particularly on disorders of phosphorus and vitamin D metabolism and their associations with cardiovascular disease and mortality in kidney disease. He has a special interest in behavioral and environmental exposures that may modulate the impact of disordered mineral metabolism on health outcomes, particularly the emerging interface between socioeconomic status, nutrition, and mineral metabolism in health and in kidney disease. In addition to these efforts, Dr. Gutierrez is also examining the interconnections between disorders of iron and mineral metabolism, particularly as they relate to the management of anemia in patients with chronic kidney disease.

Publications

  1. Marcelino J, Carpten JD, Suwairi WM, Gutiérrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML. CACP, Encoding a Secreted Proteoglycan, is Mutated in Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome. Nature Genetics 1999; 23: 319-322. [PMID 10545950]
  2. Gutiérrez O, Isakova T, Rhee E, Holmes J, Collerone G, Jueppner H, Wolf M. Fibroblast Growth Factor 23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease. J Am Soc Nephrol 2005; 16:2205-15. [PMID 15917335]
  3. Bhan I, Shah A, Holmes J, Isakova T, Gutiérrez O, Burnett SA, Jueppner H, Wolf M. Post-transplant hypophosphatemia: “Tertiary Hyper-Phosphatoninism?” Kidney Int 2006; 70:1486-94. [PMID 16941023]
  4. Wolf M, Shah A, Gutiérrez O, Ankers E, Monroy M, Tamez H, Steele D, Chang Y, Camargo CA, Tonelli M, Thadhani R. Vitamin D Levels and early mortality among incident hemodialysis patients. Kidney Int 2007 72:1004-13. [PMID 17687259]
  5. Isakova T, Gutiérrez O, Shah A, Castaldo L, Holmes J, Lee H, Wolf M. Postprandial Calcium and Phosphorus Metabolism in the Pathogenesis of Secondary Hyperparathyroidism in Early Chronic Kidney Disease. J Am Soc Nephrol 2008; 19:615-623. [PMID 18216315, PMC2391049]
  6. Gutiérrez OM, Isakova T, Andress D, Levin A, Wolf, M. Prevalence and Severity of Disordered Mineral Metabolism in Blacks with Chronic Kidney Disease. Kidney Int 2008; 73: 956-962. [PMID 18256597]
  7. Wolf M, Betancourt J, Chang Y, Shah A, Teng M, Tamez H, Gutiérrez O, Camargo CA, Melamed M, Norris K, Stampfer MJ, Powe NR, Thadhani R. Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients. J Am Soc Nephrol 2008; 19:1379-88. [PMID 18400938, PMC2440300]
  8. Gutiérrez OM, Tamez H, Bhan I, Zazra J, Tonelli M, Wolf M, Januzzi JL, Chang Y, Thadhani R. N-terminal pro-B-type Natriuretic Peptide Concentrations in Hemodialysis Patients: Prognostic Value of Baseline and Follow-up Measurements. Clin Chem 2008; 54: 1339-48. [PMID 18539645]
  9. Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, Smith K, Lee H, Thadhani R, Jüppner H, Wolf M. Fibroblast Growth Factor 23 and Mortality among Hemodialysis Patients. N Engl J Med 2008; 359:584-592. [PMID 18687639, PMC2890264]
  10. Isakova T, Gutiérrez OM, Chang Y, Shah A, Tamez H, Smith K, Thadhani R, Wolf M. Phosphorus Binders and Survival on Hemodialysis. J Am Soc Nephrol 2009;20:388-96. [PMID 19092121, PMC2637053]
  11. Lee PS, Kartik S, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutiérrez O, Wolf M, Chang Y, Stossel T, Thadhani R. Plasma Gelsolin, Circulating Actin, and Chronic Hemodialysis Mortality. J Am Soc Nephrol 2009; 20:1140-8. [PMID 19389844, PMC2678046]
  12. Gutiérrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, Sarwar A, Hoffmann U, Coglianese E, Christenson R, Wang TJ, DeFilippi C, Wolf M. Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease. Circulation, 2009; 119:2545-2552. [PMID 19414634, PMC2740903]
  13. Patel NM, Gutiérrez OM, Andress DL, Coyne DW, Levin A, Wolf M.  Vitamin D Deficiency and Anemia in Early Chronic Kidney Disease. Kidney Int Apr 2010; 77:715-20.  [PMID 20130525]
  14. Gutiérrez OM, Isakova T, Smith K, Epstein M, Patel N, Wolf M. Racial Differences in Postprandial Mineral Ion Handling in Health and in Chronic Kidney Disease. Nephrol Dial Transplant  2010; 25(12):3970-7. [PMID 20530498, PMC3108369]
  15. Gutiérrez OM, Anderson C, Isakova T, Scialla J, Negrea L, Anderson AH, Bellovich K, Chen J, Robinson N, Ojo A, Lash J, Feldman HI, Wolf M. Low Socioeconomic Status Associates with Higher Serum Phosphate Irrespective of Race. J Am Soc Nephrol. 2010; 21: 1953-1960. [PMID 20847142, PMC3014009]
  16. Isakova T, Gutiérrez OM, Patel NM, Andress DL, Wolf M, Levin A. Vitamin D Deficiency, Inflammation and Albuminuria in Chronic Kidney Disease: Complex Interactions. J Renal Nutr. 2011; 21(4):295-302 [PMID 20817560]
  17. Gutiérrez OM, Isakova T, Enfield G, Wolf M. Impact of Poverty on Serum Phosphate Concentrations in the Third National Health and Nutrition Examination Survey. J Renal Nutr. 2011; 21(2): 140-8. [PMID 20537917, PMC293723]
  18. Isakova T, Gutiérrez OM, Smith K, Epstein M, Keating LK, Jüppner H, Wolf M. Pilot Study of Dietary Phosphorus Restriction and Phosphorus Binders to Target Fibroblast Growth Factor 23 in Patients with Chronic Kidney Disease. Nephrol Dial Transplant 2011; 26(2): 584-91. [PMID 20631407, PMC3108359]
  19. Gutiérrez OM, Farwell WR, Kermah D, Taylor EN. Racial Differences in the Relationship Between Vitamin D, Bone Mineral Density and Parathyroid Hormone in the National Health and Nutrition Examination Survey. Osteoporosis Int. 2011; 22(6):1745-53. [PMID 20848081, PMC3093445]
  20. Isakova T, Anderson CA, Leonard MB,  Xie D, Gutiérrez OM, Rosen LK, Theurer J, Bellovich K, Steigerwalt SP, Tang I, Anderson AH, Townsend RR, He J, Feldman HI, Wolf M. Diuretics, Calciuria and Secondary Hyperparathyroidism in the Chronic Renal Insufficiency Cohort.  Nephrol Dial Transplant, 2011; 26(4):1258-1265. [PMID 21382989, PMC3108352]
  21. Isakova T, Wahl P, Vargas G, Gutiérrez OM, Scialla J, Xie H, Appleby D, Nessel L, Bellovich K, Chen J, Hamm L, Gadegbeku C, Horwitz E, Townsend RR, Anderson CA, Lash JP, Hsu C, Leonard MB, Wolf M. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int., 2011; 79(12): 1370-8. [PMID 21389978, PMC3134393]
  22. Carvalho C, Isakova T, Collerone G, Olbina G, Wolf M, Westerman M, Gutiérrez OM.  Hepcidin and Disordered Mineral Metabolism in Chronic Kidney Disease. Clin Nephrol, 2011; 76(2):90-8. [PMID 21762639]
  23. Isakova T, Xie H, Yang W, Xie D, Anderson AH, Scialla J, Wahl P, Gutiérrez OM, Steigerwalt S, He J, Schwartz S, Lo J, Ojo A, Sondheimer J, Hsu CY, Lash J, Leonard M, Kusek JW, Feldman HI, Wolf M. Fibroblast Growth Factor 23 and Risks of Mortality and End-Stage Renal Disease in Patients with Chronic Kidney Disease. JAMA 2011; 305(23):2432-2439. [PMID 21673295, PMC3124770].
  24. Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St. John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-o M, Kusek JW, Keane MG, Wolf M.  Fibroblast growth factor 23 induces left ventricular hypertrophy. J Clin Invest 2011;121(11):4393-408. [PMID 21985788, PMC3204831]
  25. Bowling CB, Inker LA, Gutiérrez OM, Allman RM, Warnock DG, McClellan W, Muntner P.  Age-specific associations of reduced estimated glomerular filtration rate with concurrent chronic kidney disease complications. Clin J Am Soc Nephrol 2011; 6(12):2822-8.  [PMID 22034504, PMC3255373]
  26. Gutiérrez OM, Wolf M, Taylor EN. Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the Health Professionals Follow-Up Study. Clin J Am Soc Nephrol 2011; 6(12):2871-8. [PMID 22034506, PMC3255372].
  27. Rizk D, Gutiérrez OM, Levitan EB, McClellan WB, Safford M, Soliman EZ, Warnock DG, Muntner P. Prevalence and prognosis of unrecognized myocardial infarctions in chronic kidney disease. Nephrol Dial Transplant 2012; 27(9):3482-8.  [PMID 22167594,  PMC3433770]
  28. Houston J, Smith K, Isakova T, Sowden N, Wolf M, Gutiérrez OM. Associations of  Dietary Phosphorus Intake, Urinary Phosphate Excretion and Fibroblast Growth Factor 23 with Vascular Stiffness in Chronic Kidney Disease. J Renal Nutr 2013; 23(1):12-20 [PMID 22406119, PMC3378791]
  29. Gutiérrez OM, Katz R, Peralta CA, de Boer IH, Siscovick D, Wolf M, Diez Roux A, Kestenbaum B, Nettleton JA, Ix JH. Associations of Socioeconomic Status and Processed Food Intake with Serum Phosphorus in Community-Living Adults: the Multi-Ethnic Study of Atherosclerosis. J Renal Nutr 2012; 22(5):480-9. [PMID 22217539, PMC3321388]
  30. Gutiérrez OM, Smith KT, Barchi-Chung A, Patel NM, Isakova T, Wolf M. (1-34) parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers.  Clin J Am Soc Nephrol 2012; 7(1):139-45. [PMID: 22246283, PMC3265347]
  31. Wahl P, Xie H, Scialla J, Anderson CA, Bellovich K, Brecklin C, Chen J, Feldman H, Gutiérrez OM, Lash J, Leonard MB, Negrea L, Rosas S, Anderson AH, Townsend RR, Wolf M, Isakova T.  Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. Diabetes Care 2012; 35(5):994-1001. [PMID:22446176, PMC3329844]
  32. Nielsen SE, Reinhard H, Zdunek D, Hess G, Gutiérrez OM, Wolf M, Parving HH, Jacobsen PK, Rossing P. Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patients. Diabetes Res Clin Pract. 2012; 97(1):71-6. [PMID 22402396]
  33. Bell EK, Gao L, Judd S, Glasser SP, McClellan W, Gutiérrez OM, Safford M, Lackland DT, Warnock DG, Muntner P.  Blood pressure indices and end-stage renal disease risk in adults with chronic kidney disease. Am J Hypertens. 2012; 25(7):789-96. [PMID: 22573012, PMC 3784349].
  34. Gutiérrez OM, Judd SE, Muntner P, Rizk DV, McClellan WM, Safford MM, Cushman M, Kissela BM, Howard VJ, Warnock DG.  Racial differences in albuminuria, kidney function and risk of stroke. Neurology. 2012; 79(16):1686-92 [PMID: 22993285, PMC3468778]
  35. Alvarez JA, Law J, Coakley K, Zughaier S, Wassie H, Gutiérrez OM, Ziegler TR, Tangpricha V.  High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.  Am J Clin Nutr 2012; 96(3):672-9. [PMID: 22854402, PMC3417221].
  36. Smith K, de Filippi C, Isakova T, Gutiérrez OM, Laliberte K, Seliger S, Kelley W, Duh S, Hise M, Christenson R, Wolf M, Januzzi J. Fibroblast growth factor 23, high-sensitivity cardiac troponin and left ventricular hypertrophy in chronic kidney disease.  Am J Kidney Dis 2013; 61(1): 67-73 [PMID 22883134] [PMC3525738].
  37. Gutiérrez OM, Sun CC, Chen W, Babitt JL, Lin HY. Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans.  Am J Nephrol 2012; 36(4):332-333. [PMID 23006450]
  38. Hanks LJ, Newton AL, Ashraf AP, Gutiérrez OM, Casazza K. Reduced-carbohydrate, weight loss diet is associated with greater bone mineral content in obese African-American girls. J Diabetes Res Clin Metab 2012; 1:9.
  39. Tanner RM, Gutiérrez OM, Judd S, McClellan W, Bowling CB, Bradbury B, Safford MM, Cushman M, Warnock D, Muntner P.  Geographic variation in chronic kidney disease prevalence and end stage renal disease incidence in the United States: results from the REGARDS study. Am J Kidney Dis 2012; 61(3): 395-403 [PMID 23228944] [PMC3659181].
  40. Tuot DS, Plantinga LC, Judd SE, Muntner P, Hsu CY, Warnock DG, Gutiérrez OM, Safford M, Powe NR, McClellan MM.  Healthy behaviors, risk factor control and awareness of chronic kidney disease.  Am J Nephrol 2013; 37(2):135-143 [PMID 23392070] [PMC3649001].
  41. Isakova T, Barchi-Chung A, Enfield G, Smith K, Vargas G, Houston J, Xie H, Wahl P, Schiavenato E, Dosch A, Gutiérrez OM, Diego J, Lenz O, Contreras G, Mendez A, Weiner RB, Wolf M.  Effects of dietary phosphate restriction and phosphate binders on FGF23 levels in CKD.  Clin J Am Soc Nephrol 2013;8(6):1009-18. [PMID 23471131] [PMC3675851]
  42. Muntner P, Judd SE, Gao L, Gutiérrez OM, Rizk DV, McClellan W, Cushman M, Warnock DG. Cardiovascular risk factors and end-stage renal disease and mortality risk.  J Am Soc Nephrol 2013; 24(7):1159-65. [PMC3699822]
  43. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutiérrez OM, Irvin MR, Lackland DT, Oparil S, Warnock D, Muntner P.  Prevalence of apparent treatment-resistant hypertension among individuals with CKD.  Clin J Am Soc Nephrol 2013; 8(9):1583-90. [PMID 23868902][PMC3805064]
  44. Baber U, Gutiérrez OM, Levitan E, Warnock DG, Farkouh M, Tonelli M, Safford M, Muntner P. Risk for recurrent coronary heart disease and all-cause mortality among individuals with chronic kidney disease compared with diabetes mellitus, metabolic syndrome, and cigarette smokers.  Am Heart J 2013; 166(2):373-380. [PMID 23895822]
  45. Gutiérrez OM, Khodneva YA, Muntner P, Rizk DV, McClellan WM, Cushman M, Warnock DG, Safford MM.  Association between urinary albumin excretion and coronary heart disease in black versus white adults.  JAMA 2013; 310(7):706-713. [PMID 23989654] [PMC3837520]
  46. Hanks LJ*, Tanner RM, Muntner P, Kramer H, McClellan WM, Warnock DG, Judd SE, Gutiérrez OM. Metabolic subtypes and risk of mortality in normal weight, overweight and obese individuals with CKD.  Clin J Am Soc Nephrol 2013; 8(12): 2064-71. [PMID 24178980] [PMC3848389].
  47. Carrigan A*, Klinger A, Choquette SS, Luzuriaga-McPherson A, Bell EK, Darnell B, Gutiérrez OM. Contribution of food additives to sodium and phosphorus content of diets rich in processed foods.  J Renal Nutr. 2014; 24(1):13-19. [PMID 24355818] [NIHMSID 524831][PMC3869975]
  48. Judd SE, Gutiérrez OM, Newby PK, Howard G, Howard VJ, Locher JL, Kissela BM, Shikany JM.  Dietary patterns are associated with incident stroke and contribute to excess risk of stroke in Black Americans.  Stroke 2013; 44(1):3305-11. [PMID 24159061] [PMC3898713]
  49. Chang AR, Lazo M, Appel LJ, Gutiérrez OM, Grams ME.  High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III.  Am J Clin Nutr. 2013; 99(2):320-7. [PMC3893724].
  50. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutiérrez OM, Irvin MR, Lackland DT, Oparil S, McClellan W, Warnock DG, Muntner P.  Incident ESRD and treatment-resistant hypertension: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.  Am J Kidney Dis. 2014; 63(5):781-8. [PMC4141647]
  51. Gutiérrez OM, Muntner P, Rizk DV, McClellan WM, Warnock DG, Newby PK, Judd SE. Dietary patterns and risk of death and progression to ESRD in individuals with CKD: a cohort study. Am J Kidney Dis. 2014; 64(2):204-13. [PMC4111976]
  52. Cushman M, Judd SE, Howard VJ, Kissela B, Gutiérrez OM, Jenny NS, Ahmed A, Thacker EL, Zakai NA. N-terminal pro-B-type natriuretic peptide and stroke risk: the REasons for Geographic and Racial Differences in Stroke cohort. Stroke. 2014; 45(6):1646-50 [PMID 24757103].
  53. Bowling CB, Booth JN, Gutiérrez OM, Kurella Tamura M, Huang L, Kilgore M, Judd S, Warnock DG, McClellan W, Allman RM, Muntner P. Nondisease-specific problems and all-cause mortality among older adults with CKD: The REGARDS study. Clin J Am Soc Nephrol. 2014; 9(10):1737-45. [PMC4186504]
  54. Hanks LJ*, Casazza K, Ashraf AP, Wallace S, Gutiérrez OM. Fibroblast growth factor 21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females.  Clin Endocrinol (Oxf.); 2015;82(4):550-6.  [PMID 25039824] [PMC4289452]
  55. Colantonio LD, Baber U, Banach M, Tanner RM, Warnock DG, Gutiérrez OM, Safford MM, Wanner C, Howard G, Muntner P. Contrasting the KDIGO and the ACC/AHA cholesterol management guidelines for initiation of statin therapy for adults with chronic kidney disease. J Am Soc Nephrol. 2015; 26(5):1173-80. [PMID 25395432] [PMC 4413767]
  56. Muntner P, Gutiérrez OM, Zhao H, Fox CS, Wright NC, Curtis JR, McClellan W, Wang H, Kilgore M, Warnock DG, Bowling CB. Validation study of Medicare claims to identify older adults with CKD using the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.  Am J Kidney Dis. 2015; 65(2):249-58. PMID 25242367 [PMC25242367]
  57. Fedewa SA, McClellan WM, Judd SE, Gutiérrez OM, Crews DC.  The association between race and income on risk of mortality in patients with moderate chronic kidney disease.  BMC Nephrol. 2014; 15(1):136. [PMC4144698]
  58. Panwar B*, Hanks LJ, Tanner RM, Muntner P, Kramer H, McClellan WM, Warnock DG, Judd SE, Gutiérrez OM. Obesity, metabolic health and risk of end-stage renal disease.  Kidney Int. 2015; 87(6):1216-22.  [PMC4449828]
  59. Crews DC, Gutiérrez OM, Fedewa SA, Luthi JC, Shoham D, Judd S, Powe NR, McClellan WM. Low Income, Community Poverty and Risk of End Stage Renal Disease.  BMC Nephrol. 2014; 15(1):192. [PMC4269852]
  60. Panwar B*, Jenny NS, Howard VJ, Wadley WG, Muntner P, Kissela BM, Judd SE, Gutiérrez OM. Fibroblast growth factor 23 and risk of incident stroke in community-dwelling adults. Stroke 2015; 46(2):322-8. PMID 25563643 NIHMS647876 [PMC4308535]
  61. Patel SJ, Hanks LJ, Ashraf AP, Gutiérrez OM, Casazza K. Effects of 8 week resistance training on lipid profile and insulin levels in overweight/obese peri-pubertal boys. J Diab Res Clin Metab. 2015; 4:2.
  62. Hanks LJ*, Gutiérrez OM, Bamman MM, Ashraf A, McCormick KL, Casazza K. Circulating levels of fibroblast growth factor-21 increase with age independently of body composition differences among healthy individuals. J Clin Trans Endocrinol. 2015; 2(2):77-82. [PMID 26042208] [PMC4450097]
  63. Hanks LJ*, Gutiérrez OM, Ashraf A, Casazza K. Bone mineral content as a driver of energy expenditure in prepubertal boys. J Pediatr. 2015; 166(6):1397-403. [PMC4446221]
  64. Hanks LJ*, Casazza K, Judd SE, Jenny NS, Gutiérrez OM. Associations of fibroblast growth factor 23 with markers of inflammation, insulin resistance and obesity in adults. PLoS One 2015; 10(3). [PMC4374938]
  65. Powell TC, Donnelly JP, Gutiérrez OM, Griffin RL, Safford MM, Wang HE. Cystatin C and long term risk of community-acquired sepsis: a population-based cohort study. BMC Nephrol. 2015; 16(1):61. [PMC4413986]
  66. Gutiérrez OM, Judd SE, Irvin MR, Zhi D, Limdi N, Palmer ND, Rich SS, Sale MM, Freedman BI. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans. Nephrol Dial Transplant 2016; 31:602-608. [PMID 26152403] [PMC 4805128]
  67. Bentley AR, Divers J, Shriner D, Doumatey AP, Gutiérrez OM, Adeyemo AA, Freedman BI, Rotimi CN. APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans. BMC Genomics 2015; 16:421. [PMC4448293]
  68. Kramer H, Gutiérrez OM, Judd SE, Muntner P, Warnock DG, Tanner RM, Panwar B, Shoham DA, McClellan W. Waist circumference, body mass index, and end-stage renal disease in the REGARDS (REasons for Geographic and Racial Differences in Stroke) Study. Am J Kidney Dis. 2016; 67(1):62-9  [PMID 26187471]
  69. Gutiérrez OM, Judd SE, Voeks JH, Carson AP, Safford MM, Shikany JM, Wang HE. Diet patterns and risk of sepsis in community-dwelling adults: a cohort study. BMC Infect Dis. 2015; 15:231. [PMID 26072206] PMC4465736
  70. Colantonio LD, Tanner RM, Warnock DG, Gutiérrez OM, Judd S, Muntner P, Bowling CB. The role of cystatin-C in the confirmation of reduced glomerular filtration rate among the oldest old.  Arch Med Sci. 2016; 12(1):55-67. PMC4754366
  71. Judd SE, Morgan CJ, Panwar B, Howard VJ, Wadley VG, Jenny NS, Kissela BM, Gutiérrez OM. Vitamin D deficiency and incident stroke risk in community-living black and white adults. Int J Stroke. 2016; 11(1):93-102. PMID: 26763025; PMC4920062
  72. Gutiérrez OM, Luzuriaga-McPherson A, Lin Y, Gilbert LC, Ha SW, Beck GR Jr. Impact of phosphorus-based food additives on bone and mineral metabolism. J Clin Endocrinol Metab 2015; 100(11):4264-71. PMID 26323022. PMC4702463
  73. Ilori TO, Ro YS, Kong SY, Gutiérrez OM, Ojo AO, Jedd SE, Narayan KMV, Goodman M, Plantinga L, McClellan W. Oxidative balance score and chronic kidney disease. Am J Nephrol. 2015; 42:320-327. PMID 26569393 PMC4689189
  74. Wang HE, Powell TC, Gutiérrez OM, Griffin R, Safford MM. Pre-hospitalization risk factors for acute kidney injury during hospitalization for serious infections in the REGARDS cohort. Nephron Extra 2015; 5(3):87-99. PMC4677710
  75. Tanner RM, Woodward M, Peralta C, Warnock DG, Gutiérrez O, Shimbo D, Kramer H, Katz R, Muntner P. Validation of an Albuminuria Self-assessment Tool in the Multi-Ethnic Study of Atherosclerosis (MESA). Ethn Dis. 2015; 25(4):427-434. PMC4671433
  76. Gutiérrez OM, Parsa A, Isakova T, Scialla JJ, Chen J, Flack JM, Nessel LC, Gupta J, Bellovich KA, Steigerwalt S, Sondheimer JH, Wright JT, Feldman HI, Kusek JW, Lash JP, Wolf M. Genetic African ancestry and markers of mineral metabolism in chronic kidney disease: findings from the CRIC Study. Clin J Am Soc Nephrol. 2016; 11(4): 653-662. PMID 26912553 PMC4822668
  77. Bowling CB, Bromfield SG, Colantonio LD, Gutiérrez OM, Shimbo D, Reynolds K, Wright NC, Curtis JR, Judd SE, Franch H, Warnock DG, McClellan W, Muntner P. Association of reduced glomerular filtration rate and albuminuria with serious fall injuries among older adults: findings from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Clin J Am Soc Nephrol 2016; 11(7): 1236-43. PMID:27091516 PMC4934847
  78. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR, Gutiérrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study. Bone. 2016; 87:71-7. PMID: 27032714  PMC4862915
  79. Rostand SG, McClure LA, Kent ST, Judd SE, Gutiérrez OM. Blood pressure, sunlight, and vitamin D. J Hyperten. 2016; 34(9):1704-10  PMID: 27379541
  80. Panwar B*, Judd SE, Warnock DG, McClellan WM, Booth JN, Muntner P, Gutiérrez OM. Hemoglobin concentration and risk of incident stroke in community-living adults. Stroke 2016; 47(8):2017-24. NIHMSID 794264 PMC4961542
  81. Jackson JL*, Judd SE, Panwar B, Howard VJ, Wadley VG, Jenny NS, Gutiérrez OM. Associations of 25-hydroxyvitamin D with markers of inflammation, insulin resistance and obesity in black and white community-dwelling adults. J Clin Trans Endocrinol. 2016; 5:21-25. NIHMSID 797058 PMC5098550
  82. Ku E, Gassman J, Appel LJ, Smogorzewski M, Sarnak MJ, Glidden DV, Bakris G, Gutiérrez OM, Hebert LE, Ix JH, Lea J, Lipkowitz MS, Norris K, Ploth D, Pogue VA, Rostand SG, Siew ED, Sika M, Tisher CC, Toto R, Wright Jr JT, Wyatt C, Hsu CY. BP control and long-term risk of ESRD and mortality.  J Am Soc Nephrol 2017; 28(2):617-677. PMID: 27516235. PMC5280023
  83. Deo R, Khodneva YA, Shlipak MG, Soliman EZ, Judd SE, McClellan WM, Brown TM, Rhodes JD, Gutiérrez OM, Shah SJ, Albert CM, Safford MM. Albuminuria, Kidney Function and Sudden Cardiac Death: Findings from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Heart Rhythm. 2017; 14(1):65-71. PMID: 27523775. PMC5256547
  84. Panwar B*, Judd SE, Howard VJ, Jenny NS, Wadley VG, Gutiérrez OM.  Vitamin D, Fibroblast Growth Factor 23 and Incident Cognitive Impairment: Findings from the REGARDS Study.  PLoS One 2016; 11(11):e0165671. PMID 27812184 PMC5094718
  85. Drew DA, Katz R, Kritchevsky S, Ix J, Shlipak M, Gutiérrez OM, Newman A, Hoofnagle A, Fried L, Semba RD, Sarnak M. Association between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study. J Am Soc Nephrol. 2017; [Epub ahead of print]. PMID 28104822
  86. Naik RP, Irvin MR, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR, Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp Jeffery B, Winkler CA, Cushman M. Sickle cell trait and end-stage renal disease in African Americans. J Am Soc Nephrol. 2017; [Epub ahead of print]. PMID: 28280138.
  87. Garimella PS, Katz R, Ix JH, Fried L, Kritchevsky SB, Devarajan P, Bennett MR, Parikh CR, Shlipak MG, Harris TB, Gutiérrez OM, Sarnak MJ. Association of Urinary Uromodulin with Kidney Function Decline and Mortality: the Health ABC Study. Clin Neph 2017; [Epub ahead of print]. PMID: 28332475
  88. Ilori TO, Wang X, Huang M, Gutiérrez OM, Narayan KM, Goodman M, McClellan W, Plantinga L, Ojo AO. Oxidative balance score and the risk of end-stage renal disease and cardiovascular disease. Am J Nephrol. 2017; 45(4):338-345. PMID: 28285313
  89. Chen TK, Estrella MM, Vittinghoff E, Lin F, Gutiérrez OM, Kramer H, Lewis CE, Kopp JB, Allen NB, Winkler CA, Bibbins-Domingo KB, Peralta CA. APOL1 genetic variants and longitudinal blood pressure in young adults. Kidney Int. 2017; [Epub ahead of print]. PMID: 28545715, PMC5610603
  90. Thomas B, Matsushita K, Abate KH, Al-Aly Z, Ärnlöv J, Asayama K, Atkins R, Badawi A, Ballew SH, Banerjee A, Barregård L, Barrett-Connor E, Basu S, Bello AK, , Bergstrom J, Bikbov B, Blosser C, Brenner H, Carrero JJ, Chadban S, Cirillo M, Cortinovis M, Courville K, Dandona L, Dandona R, EstepBensenor I K, Fernandes J, Fischer F, Fox C, Gansevoort RT, Gona PN, Gutiérrez OM, Hamidi S, Hanson SW, Himmelfarb J, Jassal SK, Jee SH, Jha V, Jimenez-Corona A, Jonas JB, Kengne AP, Khader Y, Khang YH, Kim YJ, Klein B, Klein R, Kokubo Y, Kolte D, Lee K, Levey AS, Li Y, Lotufo P, El Razek HMA, Mendoza W, Metoki H, Mok Y, Muraki I, Muntner PM, Noda H, Ohkubo T, >Ortiz A, Perico N, >Polkinghorne K, Al-Radaddi R, Remuzzi G, Roth G, Rothenbacher D, Satoh M, , Sawhney M, Schöttker B, Shankar A, Shlipak M, Silva DAS, Toyoshima H, Ukwaja K, Umesawa M, Vollset SE, Warnock DG, Werdecker A, Yamagishi K, Yano Y, Yonemoto N, Zaki MES, Naghavi M, Forouzanfar MH, Murray CJL, Coresh J, Vos T; Global Burden of Disease 2013 GFR Saum KUCollaborators, CKD Prognosis Consortium, and Global Burden of Disease Genitourinary Expert Group. J Am Soc Nephrol. 2017; [Epub ahead of print]. PMID: 28408440
  91. Lang J, Katz R, Ix JH, Gutiérrez OM, Peralta C, Parikh C, Saterfield S, Petrovic S, Devarajan P, Bennett M, Fried L, Cummings SR, Sarnak M, Shlipak M. Association of serum albumin levels with kidney function decline and incident chronic kidney disease in elders.  Nephrol Dial Transplant. 2017; [Epub ahead of print]; PMID: 28992097
  92. Park M, Katz R, Shlipak MG, Weiner D, Tracy R, Jotwani V, Hughes-Austin J, Gabbai F, Hsu CY, Pfeffer M, Bansal N, Bostom A, Gutiérrez O, Sarnak M, Levey A, Ix JH. Urinary markers of fibrosis and risk of cardiovascular events and death in kidney transplant recipients: the FAVORIT trial. Am J Transplant 2017; [Epub ahead of print]; PMID: 28371433
  93. Gutiérrez OM, Limou S, Lin F, Peralta CA, Kramer HJ, Carr JJ, Bibbins-Domingo K, Winkler CA, Lewis CE, Kopp JB. APOL1 nephropathy risk variants do not associate with subclinical atherosclerosis or left ventricular mass in middle-aged black adults. Kidney Int. 2018; 93:727-732. PMC5826778.
  94. Bajaj NS, Gutiérrez OM, Arora G, Judd SE, Patel N, Bennett A, Prabhu SD, Howard G, Howard VJ, Cushman M, Arora P. Racial differences in plasma NT-proBNP levels and all-cause mortality: the REGARDS study. JAMA Cardiology 2018; 3(1):11-17. PMID 29167879
  95. Chen TK, Katz R, Estrella MM, Gutiérrez OM, Kramer H, Post WS, Shlipak MG, Wassel CL, Peralta CA. Association between APOL1 genotypes and risk of cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Heart Assoc. 2017; 6(12). PMID 29269352.
  96. Walther CP, Gutiérrez OM, Cushman M, Judd SE, Lang J, McClellan W, Muntner P, Sarnak MJ, Shlipak MG, Warnock DG, Ix JH. Serum albumin concentration and risk of ESRD: the REGARDS Study. Nephrol Dial Transplant 2018; 33(10):1770-1777 . PMID: 29281114.
  97. Panwar B, Judd SE, Wadley VG, Jenny NS, Howard VJ, Safford MM, Gutiérrez OM. Association of fibroblast growth factor 23 with risk of incident coronary heart disease in community-living adults. JAMA Cardiol. 2018; 3(4):318-325.  PMID:29516098; PMC:5875372.
  98. Panwar B, McCann D, Olbina G, Westerman M, Gutiérrez OM. Effect of calcitriol on serum hepcidin in individuals with chronic kidney disease: a randomized controlled trial. BMC Nephrol 2018; 19(1):35. PMID: 29426300. PMC5807766
  99. Drew DA, Katz R, Kritchevsky S, Ix J, Shlipak M, Newman A, Hoofnagle A, Fried L, Sarnak M, Gutiérrez OM. Fibroblast growth factor 23: a biomarker of kidney function decline. Am J Nephrol. 2018; 47(4):242-250. PMID 29621752
  100. Jotwani V, Katz R, Ix JH, Gutiérrez OM, Bennett M, Parikh CR, Cummings SR, Sarnak MJ, Shlipak MG. Urinary biomarkers of kidney tubular damage and risk of cardiovascular disease and morality in elders. Am J Kidney Dis. 2018; 72(2):205-213. PMID 29602632, PMC6057830
  101. Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA. APOL1 nephropathy risk variants and incident cardiovascular disease events in community-dwelling Black adults. Circ Genom Precis Med 2018; [Epub ahead of print]. PMID 29899045
  102. Selamet U, Katz R, Ginsberg C, Rifkin DE, Fried L, Kritchevsky S, Hoofnagle AN, Bibbins-Domingo K, Drew DA, Harris TB, Newman AB, Gutiérrez OM, Sarnak MJ, Shlipak MG, Ix JH. Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging and Body Composition Study. Am J Kidney Dis. 2018; 72(3):419-428. PMID 29889525
  103. Akhabue E, Montag S, Reis JP, Pool LR, Mehta R, Yancy CW, Zhao L, Wolf M, Gutiérrez OM, Carnethon MR, Isakova T. FGF23 (Fibroblast Growth Factor-23) and Incident Hypertension in Young and Middle-Aged Adults: the CARDIA Study (Coronary Artery Risk Development in Young Adults). Hypertension. 2018; 72(1):70-76. PMID: 29712737, PMC6002950
  104. Zhao X, Geng X, Srinivasasainagendra V, Chaudhary N, Judd S, Wadley V, Gutiérrez OM, Wang H, Lange EM, Lange LA, Woo D, Unverzagt F, Safford M, Cushman M, Limdi N, Quarells R, Arnett DK, Irvin MR, Zhi D. A PheWAS study of a large observational epidemiological cohort of African Americans: the REGARDS Study. BMC Genomics 2019; 12(Suppl 1):26. PMID 30704471; PMC6357353
  105. Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutiérrez OM, Hamano T, Heine GH, Ishikawa S, Jee SH, Kronenberg F, Landray MJ, Miura K, Nadkarni GN, Peralta CA, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak M, Zhang L, van Zuilen AD, Hallan SI, Kovesdy CP, Woodward M, Levin A. Relationship of eGFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-Analysis in a Global Consortium. Am J Kidney Dis. 2019; 73(2):206-217. PMID 30348535; PMC6348050
  106. Gray MS, Wang HE, Martin KD, Donnelly JP, Gutiérrez OM, Shikany JM, Judd SE. Adherence to Mediterranean-style diet and risk of sepsis in the Reason for Geographic and Racial Differences in Stroke (REGARDS) Cohort. Br J Nutr. 2018; 120(12):1415-1421. PMID 30375291.
  107. Kempker JA, Panwar B, Judd SE, Jenny NS, Wang HE, Gutiérrez OM. Plasma 25-hydroxyvitamin D and risk of sepsis in the REGARDS cohort.  Clin Infect Dis. 2019; 68(11):1926-1931. PMID 30239610. PMC6522683
  108. Gray MS, Lakkur S, Howard VJ, Pearson K, Shikany JM, Safford M, Gutiérrez OM, Colabianchi N, Judd SE. Census track record and adherence to dietary patterns in the REGARDS cohort. Food Public Health. 2018; [Epub ahead of print]. PMID 30375291
  109. Marks KJ, Hartman TJ, Judd SE, Ilori TO, Cheung KL, Warnock DG, Gutiérrez OM, Goodman M, Cushman M, McClellan WM. Dietary oxidative balance scores and biomarkers of inflammation among individuals with and without chronic kidney disease. Nephron Extra. 2018;8(2):11-23. PMC6158582
  110. Chang AR, Grams M, Ballew SH, Bilo H, Correa A, Evans M, Gutiérrez OM, Hosseinpanah F, Iseki K, Kenealy T, Klein B, Kronenberg F, Lee BJ, Li Y, Miura K, Navaneethan SD, Roderick PJ, Valdivielso JM, Visseren FLJ, Zhang L, Gansevoort RT, Hallan SI, Levey AS, Matsushita K, Shalev V, Woodward M. Adiposity and the risk of glomerular filtration rate decline: results from a global consortium including over 5 million subjects. BMJ 2018; [Epub ahead of print]; PMID 30630856.
  111. Eaton EF, Tamhane A, Davy-Mendez T, Moore RD, Matthews WC, Saag MS, Mugavero MJ, Wyatt CM, Gutiérrez OM. Kidney dysfunction does not contribute significantly to antiretroviral therapy (ART) modification in Treatment Naïve PLWH receiving initial ART. J Acquir Immune Defic Syndr. 2019; 1:81(1):e6-e9; PMID 30865178 PMC6456383
  112. Lara KM, Levitan EB, Gutiérrez OM, Shikany JM, Safford MM, Judd SE, Rosenson RS. Dietary patterns and incident heart failure in adults with no known coronary disease. J Am Coll Cardiol. 2019; 73(16):2036-2045. PMID 31023426, PMC6501554
  113. Bailey LN*, Levitan EB, Judd SE, Sterling MR, Goyal P, Cushman ME, Safford MM, Gutiérrez OM. Association of urine albumin excretion with incident heart failure hospitalization in community-dwelling adults. JACC Heart Fail. 2019; 7(5):394-401. NIHMSID 1523781 PMID 31047019
  114. Patel N, Gutiérrez OM, Arora G, Howard G, Howard VJ, Judd SE, Prabhu SD, Levitan EB, Cushman M, Arora P. Race-based demographic, anthropometric, and clinical correlates of N-terminal pro-B-type natriuretic peptide.  Int J Cardiol. 2019; 286:145-151. PMID 30878238
  115. Gutiérrez OM, Irvin MR, Zakai NA, Naik RP, Chaudhary NS, Estrella MM, Limou S, Judd SE, Cushman M, Kopp JB, Winkler CA. APOL1 nephropathy risk alleles and mortality in African-American adults: a cohort study.  Am J Kidney Dis. 2019 (in press).
  116. Patel N, Cushman M, Gutiérrez OM, Howard G, Safford MM, Muntner P, Durant RW, Prabhu SD, Arora G, Levitan EB, Arora P. Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDS. JCI Insight. 2019 Jun 4;5. PMID 31162140
  117. Grams ME, Surapeneni A, Ballew S, Appel L, Boerwinkle E, Boulware LE, Chen T, Coresh J , Cushman M, Gutiérrez OM, Irvin MR, Ix J, Kopp J, Kuller L, Lipkowitz M, Mukamal K, Musani S, Naik R, Pajewski N, Peralta CA, Tin A, Wassel C, Wilson J, Winkler C, Young B, Zakai NA, Freedman BI. APOL1 kidney-risk variants and cardiovascular disease: an individual participant meta-analysis. J Am Soc Nephrol. 2019 Aug 5;. doi: 10.1681/ASN.2019030240. [Epub ahead of print] PubMed PMID: 31383730.
  118. Paul S*, Judd SE, Howard VJ, Safford MM, Gutiérrez OM. Association of 25-hydroxyvitamin D with incident coronary heart disease in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Am Heart J. 2019; in press. NIHMSID 1537768