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Ross Philip Holmes, Ph.D.

Ross Philip Holmes, Ph.D. Professor
Department of Urology
1530 3RD Ave S
Birmingham AL 351294-0024
Phone: (205) 9934.4933
Full CV

Ross Holmes is a Professor in the Department of Urology in the School of Medicine at the University of Alabama at Birmingham. He is the Senior Investigator in the Urology Kidney Stone Research Laboratory and is responsible for coordinating its research activities. He earned his Ph.D. degree in the Biochemistry Department of the Australian National University in Canberra, Australia studying calcium regulation of motion in the unicellular, multinuclear slime mould, Physarum polycephalum. He then studied the association of nutrition with heart disease at the University of Illinois at Champaign-Urbana before joining the faculty in the Urology Department at Wake Forest University in 1987. There he focused on kidney stone disease which was a strength of the Department, both clinically and research-wise. He noted a paucity of research on oxalate, a key component of the most common kidney stone. He has since published extensively on the contributions of oxalate consumed in the diet and that made in the body to urinary oxalate excretion and stone disease. These latter studies have included research on rare, inherited diseases that result in an over-production of oxalate and the formation of kidney stones at a young age. Since moving to the University of Alabama in 2012 to join the newly formed Department of Urology his research program has been extended to the study of the interaction between obesity and calcium oxalate stone disease. Both are quite prevalent in Alabama. This research has been funded continuously by NIH since 1996.


  • 1972 University of Queensland, Australia
    B.Sc (Biochemistry/Microbiology)
  • 1973 Australian National University, Australia
    B.Sc Hons, First Class (Biochemistry) Thesis: The synthesis of nucleic acids during the development of the blowfly, Lucilia cuprina
  • 1978 Australian National University, Australia
    Ph.D. (Biochemistry) Thesis: Regulation of calcium and actomyosin systems in Physarum polycephalum

Key Publications

  1. Cramer SD, Ferree PM, Lin K, Milliner DS, Holmes RP. The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. Hum Mol Genet 1999; 8: (11) 2063-2069.
  2. Holmes RP, Kennedy M. Estimation of the oxalate content of foods and daily oxalate intake. Kidney International 2000; 57: 1662-1667.
  3. Holmes RP, Goodman HO, Assimos DG. The contribution of dietary oxalate to urinary oxalate excretion. Kidney International 2001; 59: 270-276.
  4. Fargue S, Milliner DS, Knight J, Olson JB, Lowther WT, Holmes RP. Hydroxyproline metabolism and oxalate synthesis in Primary Hyperoxaluria. J Am Soc Nephrol. 2018 Jun;29(6):1615-1623.